| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | group | BEFREE | Protein-based mechanisms, involving restriction factors and evolutionarily conserved signaling pathways regulating transcription factors of the NF-kB and STAT families, participate in the control of viral infections in insects. | 31167955 | 2020 | ||||
|
0.070 | Biomarker | group | BEFREE | Chemical inhibition of the JAK-STAT pathway in bat cells had no effect on virus production suggesting that type I interferon signalling is not a major factor in resisting influenza virus infection. | 29636078 | 2018 | ||||
|
0.070 | Biomarker | group | BEFREE | The SVC protein Vago acts as a cross-talk molecule between the small interfering RNA (siRNA) pathway and the Jak/STAT pathway upon viral infection in Drosophila melanogaster and Culex mosquito cells. | 29074090 | 2017 | ||||
|
0.070 | Biomarker | group | BEFREE | In this review, recent progress in research of the JAK/STAT pathway activated by type I IFNs, non-canonical STAT activation, viral antagonism of the JAK/STAT pathway, removing of the JAK/STAT antagonist from viral genome for attenuation, and the potential pathogenesis roles of tyrosine phosphorylation-independent non-canonical STATs activation during virus infection are discussed in detail. | 29312301 | 2017 | ||||
|
0.070 | Biomarker | group | BEFREE | Since SUMO modification of IE1p72 has previously been shown to interfere with STAT factor binding, thus compromising the interferon-antagonistic function of this viral effector protein, our finding highlights an additional mechanism through which PML is able to restrict viral infections. | 28250117 | 2017 | ||||
|
0.070 | Biomarker | group | BEFREE | Our work uncovers novel physiological roles for two factors in viral infection: a SID protein acting independently of RNAi and a STAT protein acting in <i>C. elegans</i> antiviral immunity. | 28874466 | 2017 | ||||
|
0.070 | AlteredExpression | group | BEFREE | Curcumin was reported to display pro-apoptotic effect via the inhibition of the JAK/STAT pathway, that is overexpressed in PEL cells, as consequence of virus infection. | 28728978 | 2017 |