This study aimed to extend understanding of cellular effects of immunoglobulins from APS (aPL+) in HTR-8/SVneo cells. aPL+ IgG induced change in effector molecules important for cell invasion was investigated further.
In conclusion, PAR-1 and PAR-2 are involved in FXa-mediated intracellular Ca<sup>2+</sup> release in HUVEC and FXa reactive IgG from patients with APS and/or SLE potentiate this effect.