Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.090 AlteredExpression disease BEFREE Essential hypertension is associated with increased plasma leptin levels and decreased human soluble leptin receptor (hsLR) concentration. 17086020 2006
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ 		0.070 Biomarker disease BEFREE Essential hypertension (EH) is often accompanied by hyperinsulinemia/insulin resistance (IR) and deranged adiponectin secretion. 23822941 2013
Entrez Id: 2053
Gene Symbol: EPHX2
EPHX2 		0.010 GeneticVariation disease BEFREE Essential hypertension in Xinjiang was associated with the rs751141 G/A allele gene polymorphism in EPHX2 in Han subjects but not in Kazakh and Uygur subjects. 25966114 2015
Entrez Id: 1401
Gene Symbol: CRP
CRP 		0.050 Biomarker disease BEFREE Essential hypertension (EH) patients exhibited a marked increase in CMV IgG antibody, CRP, TNF-α, and IL-6 levels. 28837559 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.090 AlteredExpression disease BEFREE Essential hypertension (EH) patients exhibited a marked increase in CMV IgG antibody, CRP, TNF-α, and IL-6 levels. 28837559 2017
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.600 Biomarker disease BEFREE Essential hypertension has been linked to the angiotensinogen (AGT) gene in genetic linkage studies in American and European populations. 8772723 1996
Entrez Id: 2642
Gene Symbol: GCGR
GCGR 		0.040 GeneticVariation disease BEFREE Glucagon receptor gene mutation (Gly40Ser) in human essential hypertension: the PEGASE study. 10406817 1999
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.600 Biomarker disease BEFREE Angiotensinogen gene and essential hypertension in the Japanese: extensive association study and meta-analysis on six reported studies. 10459872 1999
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.100 GeneticVariation disease BEFREE Angiotensin converting enzyme gene polymorphism and activity in Turkish patients with essential hypertension. 10560791 1999
Entrez Id: 285335
Gene Symbol: SLC9C1
SLC9C1 		0.020 Biomarker disease BEFREE NHE genes play a critical role in pH homeostasis and cellular volume regulation and can be considered candidate genes for essential hypertension and renal disease. 10642288 2000
Entrez Id: 2784
Gene Symbol: GNB3
GNB3 		0.400 GeneticVariation disease BEFREE G-Protein beta(3) subunit gene variant and left ventricular hypertrophy in essential hypertension. 10642300 2000
Entrez Id: 5972
Gene Symbol: REN
REN 		0.100 GeneticVariation disease BEFREE Renin-angiotensin system genetic polymorphisms and salt sensitivity in essential hypertension. 10642351 2000
Entrez Id: 118
Gene Symbol: ADD1
ADD1 		0.400 GeneticVariation disease BEFREE alpha-adducin and angiotensin I-converting enzyme polymorphisms in essential hypertension. 11116113 2000
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.060 GeneticVariation disease BEFREE Apolipoprotein E gene polymorphism is related to metabolic abnormalities, but does not influence erythrocyte membrane lipid composition or sodium-lithium countertransport activity in essential hypertension. 11229422 2001
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.100 Biomarker disease BEFREE ACE inhibition corrected the natriuretic response to mental stress in subjects with mild essential hypertension (Deltaurinary sodium excretion, 0.05+/-0.14 mmol/min with placebo versus 0.13+/-0.19 mmol/min with ACE inhibition; P:<0.01); thus, after ACE inhibition, urinary sodium excretion increased similarly in all 3 groups. 11244019 2001
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.600 GeneticVariation disease BEFREE Angiotensin II AT1 receptor gene polymorphism and microalbuminuria in essential hypertension. 11336183 2001
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2 		0.100 Biomarker disease BEFREE HSD11B2 does not have a strong influence on the development of essential hypertension in Black people, but weaker effects on blood pressure cannot be ruled out. 11531933 2001
Entrez Id: 5972
Gene Symbol: REN
REN 		0.100 GeneticVariation disease BEFREE Renin-angiotensin system genetic polymorphisms and cerebral white matter lesions in essential hypertension. 11882570 2002
Entrez Id: 2868
Gene Symbol: GRK4
GRK4 		0.090 GeneticVariation disease BEFREE G protein-coupled receptor kinase 4 gene variants in human essential hypertension. 11904438 2002
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.600 Biomarker disease BEFREE Angiotensinogen genotype affects renal and adrenal responses to angiotensin II in essential hypertension. 11997278 2002
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1 		0.600 GeneticVariation disease BEFREE Angiotensin II type 1 receptor gene polymorphism and essential hypertension in Serbian population. 12482634 2003
Entrez Id: 6277
Gene Symbol: S100A6
S100A6 		0.010 AlteredExpression disease BEFREE PRA levels in patients with EH with the G/G genotype were significantly higher than in subjects with EH with G/A and A/A genotypes. 12574100 2003
Entrez Id: 5972
Gene Symbol: REN
REN 		0.100 GeneticVariation disease BEFREE Renin-angiotensin gene polymorphism in children with uremia and essential hypertension. 12579405 2003
Entrez Id: 5972
Gene Symbol: REN
REN 		0.100 Biomarker disease BEFREE Renin-angiotensin-aldosterone system loci and multilocus interactions in young-onset essential hypertension. 12611423 2003
Entrez Id: 5972
Gene Symbol: REN
REN 		0.100 GeneticVariation disease BEFREE Renin-angiotensin system reactivity and the constitutive capacity of the renal tubule to reabsorb sodium play a role in the individual response to diuretic therapy; therefore we evaluated the blood pressure (BP) response to hydrochlorothiazide in 87 never-treated individuals with mild essential hypertension, according to ACE gene I/D and alpha-adducin Gly460Trp polymorphism. 12623934 2003