| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | In contrast, the plasma level of the CgA-derived peptide catestatin (CST) is diminished in human essential hypertension. | 28443506 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | Thus, the accumulated evidence establishes CHGA as a novel susceptibility gene for EH. | 19943077 | 2010 | ||||
|
0.070 | Biomarker | disease | BEFREE | CHGA measurements yield insight into the pathogenesis of such human diseases as essential hypertension, in which deficiency of the catecholamine release-inhibitory CHGA fragment catestatin may trigger sympathoadrenal overactivity as an aetiologic culprit in the syndrome. | 17026486 | 2006 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | The secretory prohormone chromogranin A (CHGA) is overexpressed in essential hypertension, a complex trait with genetic predisposition, while its catecholamine release-inhibitory fragment catestatin is diminished, and low catestatin predicts augmented adrenergic pressor responses. | 16007257 | 2005 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | To evaluate chromogranin A further as a simpler or "intermediate phenotype" in the complex trait of hypertension, we studied chromogranin A expression in the spontaneously hypertensive rat (SHR), a rodent model of essential hypertension. | 10803489 | 1999 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | We evaluated hemodynamic (blood pressure, cardiac output, systemic vascular resistance, stroke volume, and cardiac contractility) and biochemical (plasma drug, catecholamine, renin, and chromogranin A levels) responses to alpha2-adrenergic blockade with intravenous yohimbine in 84 normotensive subjects stratified by genetic risk of essential hypertension (67 with positive family histories and 17 with negative family histories of hypertension), as well as 18 subjects with established essential hypertension. | 9663918 | 1998 | ||||
|
0.070 | Biomarker | disease | BEFREE | We conclude that plasma chromogranin A displays substantial heritability and is increased in established essential hypertension. | 7607727 | 1995 |