Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5972
Gene Symbol: REN
REN 		0.300 Biomarker phenotype CTD_human Withdrawal of clonidine: effects of varying dosage or duration of treatment on subsequent blood pressure and heart rate responses. 28415 1978
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.300 Therapeutic phenotype CTD_human Changes in adrenocorticotropic hormone (ACTH) and cortisol levels in drug addicts treated by a new and rapid detoxification procedure using acupuncture and naloxone. 225122 1979
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.300 Biomarker phenotype CTD_human Changes in adrenocorticotropic hormone (ACTH) and cortisol levels in drug addicts treated by a new and rapid detoxification procedure using acupuncture and naloxone. 225122 1979
Entrez Id: 4985
Gene Symbol: OPRD1
OPRD1 		0.300 Biomarker phenotype CTD_human Mu- and delta-opioid receptor-mediated epileptoid responses in morphine-dependent and non-dependent rats. 2415332 1985
Entrez Id: 551
Gene Symbol: AVP
AVP 		0.300 Biomarker phenotype CTD_human Vasopressin withdrawal produces hypotension in the spontaneously hypertensive rat. 4040330 1985
Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2 		0.300 Therapeutic phenotype CTD_human Immune response products alter CNS activity: interferon modulates central opioid functions. 2449543 1988
Entrez Id: 6869
Gene Symbol: TACR1
TACR1 		0.300 Biomarker phenotype CTD_human RP 67580, a selective antagonist of neurokinin-1 receptors, modifies some of the naloxone-precipitated morphine withdrawal signs in rats. 7692360 1993
Entrez Id: 3269
Gene Symbol: HRH1
HRH1 		0.300 Biomarker phenotype CTD_human The role of histaminergic-noradrenergic axis in naloxone-induced withdrawal symptoms in mice. 8870037 1996
Entrez Id: 3274
Gene Symbol: HRH2
HRH2 		0.300 Biomarker phenotype CTD_human The role of histaminergic-noradrenergic axis in naloxone-induced withdrawal symptoms in mice. 8870037 1996
Entrez Id: 5617
Gene Symbol: PRL
PRL 		0.300 Biomarker phenotype CTD_human Neurobehavioral syndrome induced by H2-receptor blocker withdrawal: possible role of prolactin. 9037573 1997
Entrez Id: 887
Gene Symbol: CCKBR
CCKBR 		0.300 Biomarker phenotype CTD_human The selective cholecystokininB receptor antagonist L-365,260 diminishes the expression of naloxone-induced morphine withdrawal symptoms in normal and neuropathic rats. 9496717 1998
Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1 		0.300 Biomarker phenotype CTD_human Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal. 9463367 1998
Entrez Id: 5368
Gene Symbol: PNOC
PNOC 		0.300 Therapeutic phenotype CTD_human Orphanin FQ/nociceptin inhibits morphine withdrawal. 10680585 2000
Entrez Id: 4987
Gene Symbol: OPRL1
OPRL1 		0.300 Biomarker phenotype CTD_human Enhanced spinal nociceptin receptor expression develops morphine tolerance and dependence. 11027224 2000
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1 		0.300 Biomarker phenotype CTD_human Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits. 11404432 2001
Entrez Id: 2778
Gene Symbol: GNAS
GNAS 		0.300 Biomarker phenotype CTD_human Changes of the level of G protein alpha-subunit mRNA by tolerance to and withdrawal from pentobarbital in rats. 12199159 2002
Entrez Id: 2775
Gene Symbol: GNAO1
GNAO1 		0.300 Biomarker phenotype CTD_human Changes of the level of G protein alpha-subunit mRNA by tolerance to and withdrawal from pentobarbital in rats. 12199159 2002
Entrez Id: 2770
Gene Symbol: GNAI1
GNAI1 		0.300 Biomarker phenotype CTD_human Changes of the level of G protein alpha-subunit mRNA by tolerance to and withdrawal from pentobarbital in rats. 12199159 2002
Entrez Id: 887
Gene Symbol: CCKBR
CCKBR 		0.300 Biomarker phenotype CTD_human Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system. 11880531 2002
Entrez Id: 1133
Gene Symbol: CHRM5
CHRM5 		0.300 Biomarker phenotype CTD_human Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia. 12154229 2002
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		0.300 Biomarker phenotype CTD_human Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving. 12574402 2003
Entrez Id: 2891
Gene Symbol: GRIA2
GRIA2 		0.300 Biomarker phenotype CTD_human Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. 12511956 2003
Entrez Id: 6529
Gene Symbol: SLC6A1
SLC6A1 		0.300 Therapeutic phenotype CTD_human Decrease of morphine-induced reward effects and withdrawal symptoms in mice overexpressing gamma-aminobutyric acid transporter I. 14598306 2003
Entrez Id: 2903
Gene Symbol: GRIN2A
GRIN2A 		0.300 Biomarker phenotype CTD_human Locus-specific rescue of GluRepsilon1 NMDA receptors in mutant mice identifies the brain regions important for morphine tolerance and dependence. 12878694 2003
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1 		0.300 Biomarker phenotype CTD_human Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. 12511956 2003