Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | disease | BEFREE | This case-control study was aiming to investigate the relationship between the aldosterone synthase gene (CYP11B2) biallelic polymorphism in the promoter at position -344 (-344C/T) with essential hypertension and left ventricular hypertrophy in the Egyptian population. | 30561227 | 2018 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | No consensus view has been published on the relationship between the aldosterone synthase gene (CYP11B2) -344C/T polymorphism and left ventricular hypertrophy (LVH) in Chinese Han. | 28692307 | 2017 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Some studies have focused on the relationship between -344C/T polymorphism (rs1799998) in the CYP11B2 gene and LVH, but the results are controversial. | 25208931 | 2015 | ||||
|
0.070 | GeneticVariation | disease | LHGDN | (3) There is a synergistic effect between the polymorphism of ACE gene and CYP11B2 gene to result in LVH in EH. | 12133420 | 2002 | ||||
|
0.070 | Biomarker | disease | BEFREE | Five genetic polymorphisms of the RAAS (ACE, AGTR1, AGT, CMA, CYP11B2) were analyzed in all patients and the results of genetic analysis were correlated to severity of AS and LVH to determine the importance of the polymorphisms for LVH. | 11275936 | 2001 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Hypertensive subjects with the -344 CC genotype of the aldosterone synthase promoter are characterized by a pattern of early eccentric left ventricular hypertrophy. | 11693765 | 2001 | ||||
|
0.070 | Biomarker | disease | BEFREE | We determined association of functional variants of tumor necrosis factor (TNF)- alpha, interleukin-6 (IL6), insulin-like growth factor-2 (IGF2), transforming growth factor- beta 1 (TGFB1), and aldosterone synthase (CYP11B2) genes, all previously implicated in cardiac hypertrophy, with the severity of LVH in patients with HCM. | 11113012 | 2000 |