Gene: EGFR ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 CausalMutation disease CGI
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE The epidermal growth factor receptor (EGFR) mutations occur mostly in adenocarcinomas and rarely in squamous cell carcinoma of lung. 17186532 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 Biomarker disease BEFREE Inhibition of epidermal growth factor receptor signalling reduces hypercalcaemia induced by human lung squamous-cell carcinoma in athymic mice. 17533397 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 Biomarker disease BEFREE Gain of the EGFR gene located on 7p12 is a frequent and early event in squamous cell carcinoma of the lung. 18558286 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE Epidermal growth factor receptor mutations and the clinical outcome in male smokers with squamous cell carcinoma of lung. 19543508 2009
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 Biomarker disease BEFREE Inhibition of autocrine epidermal growth factor receptor (EGFR) signaling has been shown to reduce plasma calcium and PTHrP concentrations in two lung squamous cell carcinoma xenograft models of HHM. 19825997 2009
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE This study was focused on EGFR somatic mutations and amplifications in squamous cell lung cancer. 20635059 2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 CausalMutation disease CLINVAR Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma. 20942962 2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE Detection of the EGFR mutation in exhaled breath condensate from a heavy smoker with squamous cell carcinoma of the lung. 21684624 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE Significance of epidermal growth factor receptor gene mutations in squamous cell lung carcinoma. 21318227 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease CLINVAR Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer. 22753918 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE The aim of this study was to evaluate the status of erlotinib treatment and EGFR mutation in lung SCC patients. 22420950 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 Biomarker disease BEFREE EGFR gene copy numbers were assessed by FISH and evaluated as predictors of EGFR-TKI efficacy in 71 patients with advanced squamous cell lung cancer who received gefitinib or erlotinib as a second-line or higher therapy. 22271877 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease CLINVAR MEK inhibitors reverse resistance in epidermal growth factor receptor mutation lung cancer cells with acquired resistance to gefitinib. 23102728 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE How sensitive are epidermal growth factor receptor-tyrosine kinase inhibitors for squamous cell carcinoma of the lung harboring EGFR gene-sensitive mutations? 23242440 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE Therefore, in contrast to advanced LADC, EGFR mutation testing may not be necessarily performed upfront in advanced LSQC because not only the mutation rate is low, but also the predictive value is insufficient. 25053390 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE Ten of 215 pure SQCCs (4.7%; 95% CI, 2.3%-8.4%) harbored mutations, including seven with PIK3CA, and each with AKT1, DDR2, and EGFR. 24158231 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 AlteredExpression disease BEFREE Finally, an inverse correlation was observed between Fhit and phospho-EGFR levels in a cohort of human squamous cell lung carcinoma specimens. 24464917 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinoma patients with EGFR mutations. 26216950 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 Biomarker disease BEFREE Cell membrane CD44v6 levels in squamous cell carcinoma of the lung: association with high cellular proliferation and high concentrations of EGFR and CD44v5. 25809603 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 AlteredExpression disease BEFREE Overexpression of MET and EGFR were observed in clinical specimens of lung-SCC. 25522678 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE Amplification Refractory Mutation System was used to detect the EGFR gene mutation status in the 163 SQCLC specimens. 25886585 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 Biomarker disease BEFREE Epidermal Growth Factor Receptor Inhibition in the Management of Squamous Cell Carcinoma of the Lung. 26768483 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE The Q787Q EGFR polymorphism allows stratifying lung squamous cell carcinoma patients and could be an independent prognostic marker, particularly among those in stages I and II. 26999786 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 Biomarker disease BEFREE Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Advanced Squamous Cell Lung Cancer. 26725853 2016