|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The comparison of the frequencies of DRB1 alleles in pSS patients and controls confirmed the association of the DRB1*03 allele with pSS (p = 0.02; OR = 2.36).
|
31272097 |
2020 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, HLA-DRB1*0803, a pSS risk allele, was predicted to bind to the hRo60_308-328 which contains a predominant T cell epitope of human Ro60.
|
29118759 |
2017 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results suggest that structural heterogeneity of the HLA-DRB1 peptide binding pocket P7 and P9 might play a role in the pathogenesis of pSS.
|
25582848 |
2015 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To compare the distribution of HLA-A, B, DRB1 and DQB1 alleles among Mexican patients with primary Sjögren Syndrome (pSS), secondary SS (sSS), connective tissue disease (CTD) without (w/o) SS and historical ethnically healthy controls.
|
25261962 |
2015 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DRB1*0301-DQB1*0201 haplotype and IL-10 participate in the histopathological progression of SS, autoantibody production, and clinical manifestations.
|
15846589 |
2005 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This HLA profile distinguished the SLE-SS group from the SLE-no SS group, who had an increased frequency of DRB1*1501 and DQB1*0602 alleles, but was similar to the HLA profile of the primary SS group, who had an increased frequency of DRB1*0301.
|
15022331 |
2004 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, we investigated the influence of transporters associated with antigen processing (TAP), human leukocyte antigen (HLA)-DQB1, and HLA-DRB1 gene polymorphism in mestizo Colombian patients with pSS.
|
12077712 |
2002 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results confirm the association of the DRB1*03-DQB1*02 haplotype with SS-A/SS-B autoantibodies positive pSS and demonstrate a significant association of the HLA-A24 with the disease.
|
11423179 |
2001 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Given the prominent associations with DRB1*03 and the complex dose dependent interactions at HLA-DQ, a joint contribution of HLA-DR and DQ is likely to be relevant for the formation of anti-Ro/La autoantibodies in patients with pSS.
|
11469461 |
2001 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DRB1*15 and DRB1*03 extended haplotype interaction in primary Sjögren's syndrome genetic susceptibility.
|
9844767 |
1999 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest a role of the HLA-DRB1*1501-*0301 heterozygote genotype in susceptibility to primary SS.
|
9598888 |
1998 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To better define the genetic factors that predispose to primary Sjögren's syndrome (SS), we have used polymerase chain reaction in combination with oligonucleotide probe hybridization and DNA sequencing to analyze HLA-DRB1, -DQA1, -DQB1, and -DPB1 alleles in Caucasoid (California), Japanese (Tokyo), and Chinese (Shanghai and Beijing) SS patients.
|
8468491 |
1993 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the DNA restriction fragment length polymorphism (RFLP) of the Major Histocompatability Complex (MHC) class II genes: HLA-DRB, -DQA, -DQB, DPA, and -DFB in 24 patients with rheumatoid arthritis (RA), in 19 patients with primary Sjögren's syndrome (primary SS), and healthy Danes.
|
1686751 |
1992 |