Gene: IL17A ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.100 Biomarker disease BEFREE In addition, as it is not clear whether dysregulated cytokines in pSS, interleukin (IL)-17 and IL-22 may also contribute to the EMT-dependent fibrosis process, the effect of IL-17 and IL-22 treatment on EMT-dependent SG fibrosis was evaluated in primary human salivary gland epithelial cells (SGEC) isolated from healthy subjects. 31165469 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.100 AlteredExpression disease BEFREE The association of G<i>α</i>q with interleukin-17A (IL-17A) expression was also analyzed in patients with pSS. 29977933 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.100 AlteredExpression disease BEFREE Furthermore, patients with pSS without immunosuppressive treatment show markedly higher IL-17 levels. 29476557 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.100 Biomarker disease BEFREE In line with the noticeable role of IL-17 in pSS mouse models, interference with Th17 cell generation, recruitment or effector functions (e.g. 29191572 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.100 Biomarker disease BEFREE However, the role of IL-17F, one potent inflammatory member of IL-17 family cytokines in pSS, has not been specifically defined. 28210632 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.100 Biomarker disease BEFREE Our results support further the therapeutic role in pSS of RTX that, despite its B cell specificity, appears able to also hamper IL-17-producing T cells in this disease. 26814615 2016
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.100 Biomarker disease BEFREE Circulating LEPCs were expanded in pSS and correlated with circulating Th17 cells, IL-17 and VEGF-C. 26828975 2016
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.100 Biomarker disease BEFREE γδ T cells were not significantly expanded in the salivary glands of pSS but produced more IL-17, as their percentage correlated with the focus score. 25902739 2015
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.100 AlteredExpression disease BEFREE IL-17 level and Th17 proportion of peripheral blood samples in 54 patients with pSS were analyzed simultaneously. 24420723 2014
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.100 AlteredExpression disease BEFREE IL-22, IL-23 and IL-17 were significantly increased at both protein and mRNA levels in the inflamed salivary glands of patients with pSS. 21979002 2012