The results of the meta-analysis showed that operative time [weighted mean difference (WMD): -12.95; 95%CI: -22.29 to -3.61; <i>P</i> = 0.007] and incidence of reflux gastritis/esophagitis (OR: 0.40; 95%CI: 0.20-0.80; <i>P</i> = 0.009), delayed gastric emptying (OR: 0.29; 95%CI: 0.14-0.61; <i>P</i> = 0.001), and Roux stasis syndrome (OR: 0.14; 95%CI: 0.04-0.50; <i>P</i> = 0.002) were reduced; and the level of serum albumin (WMD: 0.71; 95%CI: 0.24-1.19; <i>P</i> = 0.003) was increased in patients undergoing U-RY reconstruction compared with those undergoing RY reconstruction.