In addition, several pathways were also identified for specific brain regions, such as REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING (P value = 4.00 × 10<sup>-3</sup> ) for angular gyrus, REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR (P value = 2.22 × 10<sup>-3</sup> ) for anterior caudate, and KEGG_PRION_DISEASES (P value = 1.00 × 10<sup>-4</sup> ) for germinal matrix.