This study investigated the role of the SIP1-mediated TGF-β<sub>1</sub>/Smad signaling pathway in extracellular matrix (ECM) protein production and hypertrophic scarring.
Hypertrophic scar (HS) is a cutaneous fibrotic disorder characterized by persistent inflammation, excessive proliferation of fibroblasts, and abundant accumulation of extracellular matrix (ECM) proteins.
Hypertrophic scarring (HSc) which frequently develops in patients following severe thermal injury is characterized by accumulation of extracellular matrix (ECM) proteins including type I and type III collagen.