Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2006
Gene Symbol: ELN
ELN 		0.400 Biomarker disease HPO
Entrez Id: 4015
Gene Symbol: LOX
LOX 		0.340 Biomarker disease HPO
Entrez Id: 7048
Gene Symbol: TGFBR2
TGFBR2 		0.160 Biomarker disease HPO
Entrez Id: 7046
Gene Symbol: TGFBR1
TGFBR1 		0.150 Biomarker disease HPO
Entrez Id: 2200
Gene Symbol: FBN1
FBN1 		0.130 Biomarker disease HPO
Entrez Id: 7043
Gene Symbol: TGFB3
TGFB3 		0.120 Biomarker disease HPO
Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3 		0.110 Biomarker disease HPO
Entrez Id: 4629
Gene Symbol: MYH11
MYH11 		0.110 Biomarker disease HPO
Entrez Id: 7042
Gene Symbol: TGFB2
TGFB2 		0.110 Biomarker disease HPO
Entrez Id: 4638
Gene Symbol: MYLK
MYLK 		0.110 Biomarker disease HPO
Entrez Id: 59
Gene Symbol: ACTA2
ACTA2 		0.110 Biomarker disease HPO
Entrez Id: 4144
Gene Symbol: MAT2A
MAT2A 		0.100 Biomarker disease HPO
Entrez Id: 2301
Gene Symbol: FOXE3
FOXE3 		0.100 Biomarker disease HPO
Entrez Id: 8076
Gene Symbol: MFAP5
MFAP5 		0.100 Biomarker disease HPO
Entrez Id: 286053
Gene Symbol: NSMCE2
NSMCE2 		0.100 Biomarker disease HPO
Entrez Id: 5592
Gene Symbol: PRKG1
PRKG1 		0.100 Biomarker disease HPO
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22 		0.100 Biomarker disease HPO
Entrez Id: 59272
Gene Symbol: ACE2
ACE2 		0.350 AlteredExpression disease BEFREE <i>ACE2</i> expression was lower in infrarenal biopsies of patients with AAA than organ donors. 28935757 2017
Entrez Id: 207
Gene Symbol: AKT1
AKT1 		0.010 Biomarker disease BEFREE (3)AS-IV inhibited Bap-induced RAW264.7 macrophage cells activation by inhibiting oxidative stress and NF-κB activation through phosphatidylinositol 3-kinase (PI3-K)/AKT pathway.AS-IV is a potential preventive agent for cigarette smoking-related AAA. 29872394 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.100 AlteredExpression disease BEFREE AAA tissue contained higher levels of IL-10 compared to AOD tissue (P < 0.05). 11735270 2001
Entrez Id: 4314
Gene Symbol: MMP3
MMP3 		0.300 AlteredExpression disease BEFREE AAA wall expressed significantly more stromelysin-1 (MMP-3) (mean log(10) ratio [copy enzyme cDNA/copy GAPDH cDNA], -1.9; range, -3.3 to -0.7) than the AOD wall (mean, 4; range, -5.7 to -2.4), P<0.005. 11815431 2002
Entrez Id: 2597
Gene Symbol: GAPDH
GAPDH 		0.010 AlteredExpression disease BEFREE AAA wall expressed significantly more stromelysin-1 (MMP-3) (mean log(10) ratio [copy enzyme cDNA/copy GAPDH cDNA], -1.9; range, -3.3 to -0.7) than the AOD wall (mean, 4; range, -5.7 to -2.4), P<0.005. 11815431 2002
Entrez Id: 2006
Gene Symbol: ELN
ELN 		0.400 Biomarker disease BEFREE Abdominal aortic aneurysm (AAA) is characterized by dilatation of arterial walls, which is accompanied by degradation of elastin and collagen molecules. 16127278 2005
Entrez Id: 2006
Gene Symbol: ELN
ELN 		0.400 Biomarker disease BEFREE AAA lesions in Mcpt4(-/-) mice had fewer inflammatory cells and less apoptosis, angiogenesis, and elastin fragmentation than those of WT mice. 19720934 2009
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.050 AlteredExpression disease BEFREE Abdominal aortic aneurysm (AAA) development is associated with increased angiogenesis and overexpression of vascular endothelial growth factor (VEGF). 20471768 2010