Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 693159
Gene Symbol: MIR574
MIR574 		0.010 Biomarker disease BEFREE MiR-574-5p: A Circulating Marker of Thoracic Aortic Aneurysm. 31409059 2019
Entrez Id: 9314
Gene Symbol: KLF4
KLF4 		0.010 Biomarker disease BEFREE Tissue-Specific miRNAs Regulate the Development of Thoracic Aortic Aneurysm: The Emerging Role of KLF4 Network. 31623405 2019
Entrez Id: 49
Gene Symbol: ACR
ACR 		0.010 Biomarker disease BEFREE ACR Appropriateness Criteria<sup>®</sup> Suspected Thoracic Aortic Aneurysm. 29724424 2018
Entrez Id: 4054
Gene Symbol: LTBP3
LTBP3 		0.010 GeneticVariation disease BEFREE LTBP3 Pathogenic Variants Predispose Individuals to Thoracic Aortic Aneurysms and Dissections. 29625025 2018
Entrez Id: 406991
Gene Symbol: MIR21
MIR21 		0.010 Biomarker disease BEFREE MicroRNA-21 Knockout Exacerbates Angiotensin II-Induced Thoracic Aortic Aneurysm and Dissection in Mice With Abnormal Transforming Growth Factor-β-SMAD3 Signaling. 29519942 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.010 AlteredExpression disease BEFREE Blood and tissue homogenized levels of IL-6 and TNF-α were significantly higher in the AD group than in the AA group (p<0.001). 30088482 2018
Entrez Id: 7057
Gene Symbol: THBS1
THBS1 		0.010 Biomarker disease BEFREE Role of Thrombospondin-1 in Mechanotransduction and Development of Thoracic Aortic Aneurysm in Mouse and Humans. 30355232 2018
Entrez Id: 4638
Gene Symbol: MYLK
MYLK 		0.010 GeneticVariation disease BEFREE Fatal thoracic aortic aneurysm and dissection in a large family with a novel MYLK gene mutation: delineation of the clinical phenotype. 29544503 2018
Entrez Id: 2316
Gene Symbol: FLNA
FLNA 		0.010 GeneticVariation disease BEFREE Thoracic aortic aneurysm in patients with loss of function Filamin A mutations: Clinical characterization, genetics, and recommendations. 29334594 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.010 AlteredExpression disease BEFREE Blood and tissue homogenized levels of IL-6 and TNF-α were significantly higher in the AD group than in the AA group (p<0.001). 30088482 2018
Entrez Id: 100124700
Gene Symbol: HOTAIR
HOTAIR 		0.010 Biomarker disease BEFREE Long Non-coding RNA-mRNA Correlation Analysis Reveals the Potential Role of HOTAIR in Pathogenesis of Sporadic Thoracic Aortic Aneurysm. 28757056 2017
Entrez Id: 93663
Gene Symbol: ARHGAP18
ARHGAP18 		0.010 Biomarker disease BEFREE ARHGAP18 Protects Against Thoracic Aortic Aneurysm Formation by Mitigating the Synthetic and Proinflammatory Smooth Muscle Cell Phenotype. 28701309 2017
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.010 AlteredExpression disease BEFREE Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation. 28791384 2017
Entrez Id: 633
Gene Symbol: BGN
BGN 		0.010 GeneticVariation disease BEFREE Loss-of-function mutations in the X-linked biglycan gene cause a severe syndromic form of thoracic aortic aneurysms and dissections. 27632686 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.010 Biomarker disease BEFREE Genetic deletion of IL-1β and IL-1R significantly decreased thoracic aortic dilation (IL-1β knockout=54.2±16.8% and IL-1R knockout=62.6±17.2% versus WT TAA=104.7±23.8%; P<0.001for both). 25200056 2014
Entrez Id: 5270
Gene Symbol: SERPINE2
SERPINE2 		0.010 AlteredExpression disease BEFREE Both PN-1 and plasminogen activator inhibitor-1 mRNA and proteins were overexpressed in medial tissue extracts and primary VSMC cultures from thoracic aneurysm of the ascending aorta compared with acute ascending aortic dissection and controls. 23814118 2013
Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3 		0.010 GeneticVariation disease BEFREE Thoracic aortic aneurysm in infancy in aneurysms-osteoarthritis syndrome due to a novel SMAD3 mutation: further delineation of the phenotype. 23554019 2013
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1 		0.010 AlteredExpression disease BEFREE Both PN-1 and plasminogen activator inhibitor-1 mRNA and proteins were overexpressed in medial tissue extracts and primary VSMC cultures from thoracic aneurysm of the ascending aorta compared with acute ascending aortic dissection and controls. 23814118 2013
Entrez Id: 6283
Gene Symbol: S100A12
S100A12 		0.010 Biomarker disease BEFREE S100A12 is enriched in human thoracic aortic aneurysms and dissections. 22818064 2012
Entrez Id: 5579
Gene Symbol: PRKCB
PRKCB 		0.010 Biomarker disease LHGDN Differential protein kinase C isoform abundance in ascending aortic aneurysms from patients with bicuspid versus tricuspid aortic valves. 17846295 2007
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1 		0.010 GeneticVariation disease BEFREE We, therefore, investigated the potential relationship between mutations in regions of NOTCH1 recently reported to be associated with bicuspid aortic valve and the phenotype of bicuspid aortic valve and thoracic aortic aneurysms in unrelated patients undergoing surgical repair. 17662764 2007
Entrez Id: 2006
Gene Symbol: ELN
ELN 		0.020 Biomarker disease BEFREE Background Thoracic aortic aneurysm ( TAA ) and dissection ( TAD ) are characterized by progressive disorganization of the aortic wall matrix, including elastin, a highly immunogenic molecule. 30957625 2019
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.020 Biomarker disease BEFREE MicroRNA-21 Knockout Exacerbates Angiotensin II-Induced Thoracic Aortic Aneurysm and Dissection in Mice With Abnormal Transforming Growth Factor-β-SMAD3 Signaling. 29519942 2018
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.020 Biomarker disease BEFREE Elevated Plasma Levels of LDL Cholesterol Promote Dissecting Thoracic Aortic Aneurysms in Angiotensin II-Induced Mice. 29197606 2018
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4 		0.020 Biomarker disease BEFREE A Functional Variant of SMAD4 Enhances Thoracic Aortic Aneurysm and Dissection Risk through Promoting Smooth Muscle Cell Apoptosis and Proteoglycan Degradation. 28666732 2017