Significant differences for cytoplasmic Pin1 staining were observed between normal nevi and metastatic melanoma (P = 0.011, χ<sup>2</sup> test), between dysplastic nevi and primary melanoma (P = 0.046, χ<sup>2</sup> test) and between dysplastic nevi and metastatic melanoma (P = 0.016, χ<sup>2</sup> test).