| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Genomic characterization performed in BIA-ALCL to date has demonstrated qualitatively similar molecular abnormalities to those seen in its more common counterpart [ALK-negative systemic anaplastic large cell lymphoma (sALCL)] including JAK/STAT activation and MYC/TP53 dysregulation. | 30817557 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | These findings identify a novel recurrent <i>MSC</i> mutation as a key driver of the CD30-IRF4-MYC axis and cell cycle progression in a unique subset of ALCLs. | 31101622 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | In conclusion, we identified STAT-mediated BATF3 expression that is essential for lymphoma cell survival and promoted MYC activity in cHL and ALCL, hence we recognized a new oncogenic axis in these lymphomas. | 28659618 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Synergy was tested with combination targeted therapies.Bromodomain inhibition with OTX015 led primarily to ALCL cell cycle arrest in a dose-dependent manner, along with downregulation of MYC and its downstream regulated genes. | 27793034 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | Collectively, our results demonstrate that ALCLs are dependent on IRF4 and MYC signaling and that MYC may represent a promising target for future therapies. | 25359993 | 2015 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | This case underscores the importance of recognition of close correlation between dual ALK and MYC rearrangements and the characteristic clinical features in this unusual ALCL variant. | 23619105 | 2013 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | C-Myc may be a downstream target of ALK signaling and its expression a defining characteristic of ALK-positive ALCLs. | 12213716 | 2002 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | We identified abnormal c-myc gene products in 6 of 18 cases (33%) of ALCL. | 8204884 | 1994 |