Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.360 | GeneticVariation | disease | BEFREE | In contrast, mutations of phosphatase and tensin homolog (PTEN) and tumor protein 53 (TP53) appeared to be higher in HGG tumors in CC patients than in their AA counterparts. | 29599344 | 2018 | ||||
|
0.360 | Biomarker | disease | BEFREE | PTEN has previously been associated with cholangiocarcinoma development in murine models. | 29452147 | 2018 | ||||
|
0.360 | Biomarker | disease | CTD_human | Toll-like Receptor 4 on Macrophage Promotes the Development of Steatohepatitis-related Hepatocellular Carcinoma in Mice. | 27022031 | 2016 | ||||
|
0.360 | Biomarker | disease | BEFREE | miR-221 Promotes Epithelial-Mesenchymal Transition through Targeting PTEN and Forms a Positive Feedback Loop with β-catenin/c-Jun Signaling Pathway in Extra-Hepatic Cholangiocarcinoma. | 26501139 | 2015 | ||||
|
0.360 | AlteredExpression | disease | BEFREE | Ars2 is overexpressed in human cholangiocarcinomas and its depletion increases PTEN and PDCD4 by decreasing microRNA-21. | 22213145 | 2013 | ||||
|
0.360 | AlteredExpression | disease | BEFREE | In SCID mice with tumor xenografts, mPGES-1 overexpression accelerated tumor formation and increased tumor weight (P<.01), whereas mPGES-1 knockdown delayed tumor formation and reduced tumor weight (P<.01). mPGES-1 inhibited the expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), leading to activation of the epidermal growth factor/phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathways in cholangiocarcinoma cells. mPGES-1-mediated inhibition of PTEN is regulated through blocking of early growth response-1 sumoylation and binding to the 5'-untranslated region of the PTEN gene. | 21354147 | 2011 | ||||
|
0.360 | Biomarker | disease | BEFREE | These findings elucidate the relationship between SMAD4 and PTEN and extend our understanding of CC formation. | 16767220 | 2006 |