Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | disease | BEFREE | A phase I/II trial was performed to investigate the safety and tolerance of zosuquidar.3HCL, a potent inhibitor of P-glycoprotein (P-gp), when administered orally alone and in combination with the CHOP regimen in patients with untreated non-Hodgkin's lymphoma and to determine whether zosuquidar.3HCL affects pharmacokinetics of doxorubicin and vincristine. | 17454628 | 2007 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | No mdr1 expression was detected in 5 out of 6 of these samples, whereas a low level of mdr1 expression was found in a sample from one PLL patient in the course of transformation to non-Hodgkin's lymphoma. | 2323839 | 1990 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Polymorphisms in DNA repair genes and MDR1 and the risk for non-Hodgkin lymphoma. | 24756092 | 2014 | ||||
|
0.070 | Biomarker | disease | BEFREE | Recent data, particularly in haematological malignancies such as acute non-lymphocytic leukaemia, myeloma and non-Hodgkin's lymphoma, indicate that P-glycoprotein may be involved in the development of clinical drug resistance. | 1674435 | 1991 | ||||
|
0.070 | Biomarker | disease | BEFREE | Preliminary results suggest that some haematological malignancies, among which are acute myelocytic leukaemia, multiple myeloma and non-Hodgkin's lymphoma, might benefit from the simultaneous administration of cytotoxic drugs and P-glycoprotein inhibitors. | 7765326 | 1993 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Our results show that P-gp is expressed before treatment of non-Hodgkin's lymphoma of HIV patients, and is related to poor response to treatment and overall survival. | 17157997 | 2007 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Expression of P-glycoprotein and anionic glutathione S-transferase genes in non-Hodgkin's lymphoma. | 8094105 | 1993 |