| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Several targeted therapies-such as tyrosine kinase inhibitors targeting epidermal growth factor receptors and anaplastic lymphoma kinase-are active in NSCLC and have data to suggested possible effectiveness against brain metastases in these patients. | 30176786 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Gastric cancer with brain metastasis and the role of human epidermal growth factor 2 status. | 29552209 | 2018 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | We explored whether activating mutations of epidermal growth factor receptors (<i>EGFRs</i>) in exon 19 deletion or L858R predict BM in NSCLC. | 28881820 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. | 23794705 | 2013 | ||||
|
0.080 | Biomarker | disease | BEFREE | EGF receptor tyrosine kinase inhibitors in the treatment of brain metastases from non-small-cell lung cancer. | 23249107 | 2012 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Metastases showed significantly higher immunohistochemical expression of EGF (membrane: brain metastases 66.0 versus primary tumors 48.5; P = 0.027; nucleus: brain metastases 92.2 versus 67.4; P = 0.008), amphiregulin (nucleus: brain metastases 53.7 versus primary tumors 33.7; P = 0.019), phosphorylated EGFR (membrane: brain metastases 161.5 versus primary tumors 76.0; P < 0.0001; cytoplasm: brain metastases 101.5 versus primary tumors 55.9; P = 0.014), and phosphorylated Her3 (membrane: brain metastases 25.0 versus primary tumors 3.7; P = 0.001) than primary tumors did. | 19622585 | 2009 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Polysomy of chromosome 7 is associated with amplification and overexpression of the EGF-receptor gene in a human carcinoma cell line derived from a brain metastasis. | 1701094 | 1990 | ||||
|
0.080 | Biomarker | disease | BEFREE | Nineteen per cent (five out of 27) of the gliomas, 50% (three out of six) of the brain metastases and 0% (0 out of 11) meningiomas had an amplified EGF-receptor gene. | 2908290 | 1988 |