| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | AlteredExpression | disease | BEFREE | Patients with a solid ADC subtype and mutated genes EGFR, CTLA4, PDCD1LG2, or ZEB1 complemented with PD-L1 or p53 protein lower expression that only underwent surgical treatment who develop brain metastases may have the worst prognosis. | 30218756 | 2019 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Mutations in TP53 and PIK3CA were common in BCBM. | 29938395 | 2018 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Our NGS study of BM of ovarian carcinoma revealed a significant number of BRCA-mutations beside TP53, ATM and CHEK2 mutations. | 28497333 | 2017 | ||||
|
0.090 | Biomarker | disease | BEFREE | The aim of our study was to identify numerical aberrations of chromosome 17 and TP53 in 5 subjects with brain metastasis from breast cancer using dual-color fluorescence in situ hybridization experiments. | 23315874 | 2013 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | The data suggest that p53 overexpression occurs frequently in brain metastases and may facilitate sensitivity to Plk1 inhibition. | 21953073 | 2011 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | On the other hand, AI at chromosome regions 3p11-p14 and 9p21-p24 and p53 mutation were detected only in the mesenchymal component in the primary tumor but not in the epithelial component in the primary tumor and the brain metastasis. | 17350138 | 2007 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | The mRNA and protein expression of p53 and BCL-2 seems to be reduced in breast cancer brain metastases. | 17288732 | 2006 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | The p53 mutation detected in the deoxyribonucleic acid of the lung tumor of the control patient proved to be conserved in the lymph nodes as well as in the brain metastasis. | 8614143 | 1996 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | We examined tissue from 6 patients with primary lung carcinoma and the corresponding brain metastases for the presence of p53 mutations by immunohistochemistry. | 1331352 | 1992 |