The results show significant improvements (p <0.05) in both legs for knee joint ROM and trunk flexion in EG1 (8.9% and 25.5%; 5.7% and 20.9% in right and left leg respectively) and EG2 (6.7% and 22%; 3.9% and 24.4%), only EG1 improved muscular stiffness in BF (27.4% left leg) and ST (20.5% and 24.3%), and lateral symmetry in BF (49%) without decreasing average speed in lower limbs.
The present study aimed to clarify the associations between two genetic polymorphisms (rs2234693 and rs9340799) in the estrogen receptor 1 gene (ESR1) and muscle injury or muscle stiffness.
An index of active muscle stiffness was estimated PRE- and POST-fatigue as the slope of the linear regression established between shear modulus and absolute joint force up to 60% MVC.
The aim of the present study was to investigate how myostatin dysfunction affects fast and slow muscle stiffness and viscosity during severe repeated loading.
Recombinant vitronectin-grafted hydrogels were developed by adjusting surface charge of the hydrogels with grafting of poly-l-lysine for optimal culture of human embryonic stem cells (hESCs) under xeno- and feeder-free culture conditions, with elasticity regulated by crosslinking time (10-30 kPa), in contrast to conventional recombinant vitronectin coating dishes, which have a fixed stiff surface (3 GPa). hESCs proliferated on the hydrogels for over 10 passages and differentiated into the cells derived from three germ layers indicating the maintenance of pluripotency. hESCs on the hydrogels differentiated into cardiomyocytes under xeno-free culture conditions with much higher efficiency (80% of cTnT+ cells) than those on conventional recombinant vitronectin or Matrigel-coating dishes just only after 12 days of induction.
The present study does not support the view that COL5A1rs12722 polymorphism has a role as a risk factor for sports-related muscle injury, or that it is a determinant for passive muscle stiffness in a Japanese population.
An index of active muscle stiffness was estimated PRE- and POST-fatigue as the slope of the linear regression established between shear modulus and absolute joint force up to 60% MVC.
A CPC containing the novel GDF5 mutant BB-1 may thus represent an alternative to the bioinert, supraphysiologically stiff polymethylmethacrylate cement presently used to treat osteoporotic vertebral fractures by vertebroplasty and kyphoplasty.
The aim of the present study was to investigate the relationship between estimated muscle fiber composition (time-to-peak twitch torque; TPT) and muscle stiffness under passive and active conditions as well as stiffness of tendon structures in human plantar flexors.
The aim of the present study was to investigate the relationship between estimated muscle fiber composition (time-to-peak twitch torque; TPT) and muscle stiffness under passive and active conditions as well as stiffness of tendon structures in human plantar flexors.
This study indicates that RR and RX genotypes of the ACTN3R577X polymorphism (corresponding to the presence of α-actinin-3 in type II muscle fibers) are associated with increased passive muscle stiffness of the human hamstring in vivo.
The aim of the present study was to investigate the relationship between estimated muscle fiber composition (time-to-peak twitch torque; TPT) and muscle stiffness under passive and active conditions as well as stiffness of tendon structures in human plantar flexors.
No decrease in the intensity of the second actin layer line at reciprocal radii in the range of 0.15-0.275 nm<sup>-1</sup> was observed during shortening suggesting that an azimuthal Tpm movement from the O- to C-state does not occur, although during shortening muscle stiffness is reduced compared to the isometric state, and the intensities of other actin layer lines demonstrate a ∼2-fold decrease in the fraction of myosin heads strongly bound to actin.
Patients with chronic stiff knee with extremely restricted arc of motion (AOM ≤ 20°) may present with stiffness either in extension (stiff in extension [SE]) or in flexion (stiff in flexion [SF]).
The findings here suggest that an age-related increase in muscle stiffness drives YAP/TAZ-mediated pathogenic expression of matricellular proteins by fibroblasts, ultimately disrupting MuSC fate.
Fibulin-2 deficiency impaired the ability of tumor cells to migrate and invade in Boyden chambers, to create a stiff extracellular matrix in mice, to cross-link secreted collagen, and to adhere to collagen.
Nasal epithelial cells from the affected individual and CCDC65-specific shRNA transduced normal airway epithelial cells had stiff and dyskinetic cilia beating patterns compared to control cells.
More LRRK2 G2019S carriers reported muscle stiffness (rigidity, p = 0.007) and balance disturbances (p = 0.008), while more GBA mutation carriers reported slowness (bradykinesia, p = 0.021).
More LRRK2G2019S carriers reported muscle stiffness (rigidity, p = 0.007) and balance disturbances (p = 0.008), while more GBA mutation carriers reported slowness (bradykinesia, p = 0.021).