Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | AlteredExpression | disease | BEFREE | Several mouse models with aberrantly increased p53 activity display signs of premature aging. | 28846075 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | The clinical studies and the diverse cellular and animal models of p53 isoforms (zebrafish, Drosophila, and mouse) lead us to realize that a p53-mediated cell response is, in fact, the sum of the intrinsic activities of the coexpressed p53 isoforms and that unbalancing expression of different p53 isoforms leads to cancer, premature aging, (neuro)degenerative diseases, inflammation, embryo malformations, or defects in tissue regeneration. | 26801896 | 2016 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Accordingly, an unbalanced p53 activity gives rise to premature aging or cancer. | 22383384 | 2012 | ||||
|
0.070 | Biomarker | disease | BEFREE | The shorter isoform regulates full length p53 and in cases where there is too much of the longer isoform, this leads to elevated apoptosis resulting in decreased tumor incidence but also in premature ageing due to exhaustion of the renewal potential. | 17471501 | 2007 | ||||
|
0.070 | Biomarker | disease | BEFREE | We examined the DNA damage response of p53 and its target p21(WAF1) to UV and ionising radiation in fibroblasts from patients with the premature ageing disorder Hutchinson-Gilford Progeria (HGP). | 12735900 | 2003 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Increased p53 expression under the endogenous promoter protects "super p53" mice from tumorigenesis without the undesirable effects of premature aging. | 12498711 | 2002 | ||||
|
0.070 | Biomarker | disease | BEFREE | Mutations in WRN are found in patients with the premature aging and cancer susceptibility syndrome known as Werner syndrome (WS). p53 binds to the WRN protein in vivo and in vitro through its carboxyl terminus. | 10364153 | 1999 |