|
TMEM106B
|
0.100 |
Biomarker
|
disease |
BEFREE |
TMEM106B Effect on cognition in Parkinson disease and frontotemporal dementia.
|
30973966 |
2019 |
|
TMEM106B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity.
|
29855382 |
2018 |
|
TMEM106B
|
0.100 |
Biomarker
|
disease |
BEFREE |
As TMEM106B is a risk factor for frontotemporal dementia caused by both C9orf72 and progranulin mutations, and antisense oligonucleotides are showing promise as therapeutics for neurodegenerative diseases, our data suggests a potential new strategy for treating the wide range of frontotemporal dementias associated with endolysosomal dysfunction.
|
30496365 |
2018 |
|
TMEM106B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TMEM106B and ApoE polymorphisms in CHMP2B-mediated frontotemporal dementia (FTD-3).
|
28888721 |
2017 |
|
TMEM106B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We subsequently performed a genome-wide association study and identified the TMEM106B and GRN gene loci, previously associated with frontotemporal dementia, as determinants of Δ-aging in the cerebral cortex with genome-wide significance.
|
28330615 |
2017 |
|
TMEM106B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.
|
28728022 |
2017 |
|
TMEM106B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in TMEM106B are thought to modify disease onset in frontotemporal dementia, but its relation to myelination is not understood.
|
29186371 |
2017 |
|
TMEM106B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TMEM106B polymorphism, rs1990622 T/C) on grey matter volume in a large cohort of presymptomatic subjects bearing frontotemporal dementia-related pathogenic mutations.
|
28460069 |
2017 |
|
TMEM106B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, the finding in the stage 1 sample that AD risk is significantly influenced by the interaction of APOE with rs1595014 in TMEM106B (P=1·6 × 10(-7)) is noteworthy, because TMEM106B variants have previously been associated with risk of frontotemporal dementia.
|
25778476 |
2016 |
|
TMEM106B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.
|
27126638 |
2016 |
|
TMEM106B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of TMEM106B rs1990622 marker and frontotemporal dementia: evidence for a recessive effect and meta-analysis.
|
25096617 |
2015 |
|
TMEM106B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.
|
23742080 |
2013 |
|
TMEM106B
|
0.100 |
Biomarker
|
disease |
BEFREE |
TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.
|
22895706 |
2012 |