Gene: SDHB ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 Biomarker group BEFREE Long-term follow-up of patients with metastatic GIST treated with regorafenib suggests particular benefit among patients with primary KIT exon 11 mutations and those with SDH-deficient GIST. 27371698 2016
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 Biomarker group BEFREE Currently, little is known about differences in miRNA expression between KIT/PDGFRA mutant and KIT/PDGFRA wild-type (WT)-SDH deficient gastrointestinal stromal tumors (GIST). 27625077 2016
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Magnetic resonance imaging spectrum of succinate dehydrogenase-related infantile leukoencephalopathy. 26642834 2016
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery. 26719882 2016
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR [Intrapericardical paraganglioma associated with mutation in succinate dehydrogenase enzyme gene]. 24939699 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Succinate Dehydrogenase (SDH)-Deficient Pancreatic Neuroendocrine Tumor Expands the SDH-Related Tumor Spectrum. 26259135 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Pituitary adenoma with paraganglioma/pheochromocytoma (3PAs) and succinate dehydrogenase defects in humans and mice. 25695889 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Mitochondrial leukoencephalopathy and complex II deficiency associated with a recessive SDHB mutation with reduced penetrance. 26925370 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 Biomarker group BEFREE An alternate mechanism of oncogenesis through loss of function of the succinate-dehydrogenase (SDH) enzyme complex has been identified for a subset of these "wild type" GISTs. 26555092 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group BEFREE Genetic screening confirmed the diagnosis of Carney-Stratakis syndrome, an SDH-D germline mutation leading to GIST and multifocal paragangliomas. 25883251 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Lack of utility of SDHB mutation testing in adrenergic metastatic phaeochromocytoma. 25371406 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Genetics of Apparently Sporadic Pheochromocytoma and Paraganglioma in a Chinese Population. 26267327 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Association of urinary bladder paragangliomas with germline mutations in the SDHB and VHL genes. 25683602 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Superiority of [68Ga]-DOTATATE PET/CT to Other Functional Imaging Modalities in the Localization of SDHB-Associated Metastatic Pheochromocytoma and Paraganglioma. 25873086 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Structural and functional consequences of succinate dehydrogenase subunit B mutations. 25972245 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 Biomarker group BEFREE Among gastrointestinal stromal tumors (GISTs) of 10-15% are negative for KIT and PDGFRA, and most of these cases are SDH deficient. 25427437 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR SDHD immunohistochemistry: a new tool to validate SDHx mutations in pheochromocytoma/paraganglioma. 25405498 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 Biomarker group BEFREE SDHB immunohistochemistry is useful in characterizing GISTs with SDHA-D mutations, whereas SDHA immunohistochemistry is able to identify SDHA mutant GISTs. 25766843 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Paraganglioma Presenting as Postpartum Fever of Unknown Origin. 26236513 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group BEFREE Good survival outcome of metastatic SDH-deficient gastrointestinal stromal tumors harboring SDHA mutations. 25188872 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 Biomarker group BEFREE This study strengthens the etiological association of SDH genes with pituitary neoplasia, renal tumorigenesis, and gastric gastrointestinal stromal tumors. 26259135 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Additive effect of nuclear and mitochondrial mutations in a patient with mitochondrial encephalomyopathy. 25736212 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR 15 YEARS OF PARAGANGLIOMA: Clinical manifestations of paraganglioma syndromes types 1-5. 26273102 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Pheochromocytoma and paraganglioma syndromes: genetics and management update. 24523625 2014
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Phenotype of SDHB mutation carriers in the Netherlands. 25047027 2014