Gene: PTEN ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 GenomicAlterations disease CGI
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 CausalMutation disease CGI
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 AlteredExpression disease BEFREE PTEN and PIK3CA expression is associated with prolonged survival after gefitinib treatment in EGFR-mutated lung cancer patients. 17409929 2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 PosttranslationalModification disease BEFREE PTEN inactivation in lung cancer cells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors. 17912443 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker disease BEFREE PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. 19351834 2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker disease BEFREE Phosphatase and tensin homolog (PTEN) loss has been recently reported as a gefitinib resistance mechanism in lung cancer. 23592446 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker disease BEFREE Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a lipid and protein phosphatase and possesses an antitumor effect in lung cancers. miRNAs are reportedly abnormally expressed in human lung cancers. 28872922 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker disease BEFREE PTEN protein loss is a frequent event in lung cancer, but genetic alterations are not equally detected. 31404976 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 AlteredExpression disease BEFREE And then, we found there is a negative relationship between the expression of miR-205 and PTEN mRNA in lung cancer by analyzed. 25973003 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 GeneticVariation disease BEFREE And, it has been reported that both PTEN loss and NF-κB activation contribute to intrinsic EGFR-TKI resistance in EGFR-mutant lung cancer. 31497352 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker disease BEFREE Consistent with these findings, we observed increased PTEN phosphorylation and reduced nuclear PTEN levels in lung cancer patient samples establishing phosphorylation as a bona fide inactivation mechanism for PTEN in lung cancer. 29108454 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 GeneticVariation disease BEFREE Decreased AKT phosphorylation (S473) was significantly associated with PTEN mutation under glucose starvation conditions in lung cancer cell lines. 26573869 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 AlteredExpression disease BEFREE Down-regulation or inhibition of PRMT5 markedly reduced Akt phosphorylation at Thr308 and Ser473, whereas the expression of PTEN and mTOR phosphorylation was unchanged, indicating that PRMT5 was an important upstream regulator of Akt and induced lung cancer cell proliferation. 30461193 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 AlteredExpression disease BEFREE However, the molecular mechanism of EMT induced by PTEN inactivation is not clear in lung cancer. 30885348 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker disease BEFREE Implication of a protein-tyrosine-phosphatase in human lung cancer. 7981622 1994
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 AlteredExpression disease BEFREE In contrast, engineered gain of USP18 expression in these same lung cancer cell lines stabilized PTEN protein. 27980214 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker disease CTD_human In contrast, engineered gain of USP18 expression in these same lung cancer cell lines stabilized PTEN protein. 27980214 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 PosttranslationalModification disease BEFREE Infrequent hypermethylation of the PTEN gene in Korean non-small-cell lung cancers. 20175786 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 AlteredExpression disease BEFREE Lack of expression of PTEN is a non-sufficient condition leads to lung cancer formation alone. 23261230 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker disease BEFREE Loss of PTEN function has been detected frequently in different forms of cancers, such as breast, prostate and lung cancer, gastric and colon cancer, skin cancer, as well as endometrial carcinoma. 25773992 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker disease BEFREE MicroRNA-101 suppresses progression of lung cancer through the PTEN/AKT signaling pathway by targeting DNA methyltransferase 3A. 28123563 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker disease BEFREE Multiple primary lung cancer displaying different EGFR and PTEN molecular profiles. 27823967 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker disease BEFREE Mutations in TP53, PIK3CA, PTEN and other genes in EGFR mutated lung cancers: Correlation with clinical outcomes. 28285689 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker disease BEFREE Negative Regulation of PTEN by MicroRNA-221 and Its Association with Drug Resistance and Cellular Senescence in Lung Cancer Cells. 29876362 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.600 Biomarker disease BEFREE Other driver biomarkers in lung cancer (point mutations and rearrangements in specific genes including Her2, BRAF, NUT, MET, ROS1, DDR2, FGFR1, KRAS, and PTEN) might potentially provide additional information for clinical decision making. 24420742 2014