Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | disease | BEFREE | Differences in <i>TNF-α-863 and TNF-α-238</i> genotypes frequencies in patients with AMD and healthy controls were not found. | 30662836 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | Our results indicate that chronic TNFα-exposure is sufficient to alter RPE morphology and impede cardinal features that define the differentiated state of RPE cells with striking similarities to the alterations that are observed with age in neurodegenerative diseases such as age-related macular degeneration. | 29548329 | 2018 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Significant associations were observed with multiple previously identified AMD risk loci and 2 novel genes: HGS (peak SNP rs8070488, MAF = 0.23, OR = 0.91, p = 7.52 × 10(-5)), which plays a role in the clathrin-mediated endocytosis signaling pathway, and TNF (peak SNP rs2071590, MAF = 0.34, OR = 0.89, p = 1.17 × 10(-5)), which is a member of the atherosclerosis signaling and the LXR/RXR activation pathways. | 24439028 | 2014 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | More importantly, our data indicate that the change in ARMS2 may affect C3, C5, IL-6, IL-8, and TNF-α levels, and this may be one of the mechanisms of AMD development. | 23959158 | 2013 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Our data indicate that the tumor necrosis factor-α -1031 T/C polymorphism may be associated with wet AMD in the Taiwan Chinese population. | 21060270 | 2011 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | The down-regulation of BMP4 expression by TNF in CNV and mechanisms established might be useful for defining novel targets for AMD therapy. | 21411747 | 2011 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Both controls and AMD patients vary in the activation state (defined as TNF-alpha expression) of circulating monocytes. | 15249366 | 2004 |