| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.140 | AlteredExpression | disease | BEFREE | AMD was an independent factor associated with lower levels of angiogenin (β = -0.29, <i>p</i> < 0.001), endostatin (β = -0.18, <i>p</i> < 0.001), FGF-basic (β = -0.18, <i>p</i> < 0.001), PlGF (β = -0.24, <i>p</i> < 0.001), miRNA-21-3p (β = -0.13, <i>p</i> = 0.01) and miRNA-155-5p (β = -0.16, <i>p</i> = 0.002); and with higher levels of FGF-acidic (β = 0.11, <i>p</i> = 0.03), miRNA-23a-3p (β = 0.17, <i>p</i> < 0.001), miRNA-126-5p (β = 0.13, <i>p</i> = 0.009), miRNA-16-5p (β = 0.40, <i>p</i> < 0.001), miRNA-17-3p (β = 0.13, <i>p</i> = 0.01), miRNA-17-5p (β = 0.17, <i>p</i> < 0.001), miRNA-223-3p (β = 0.15, <i>p</i> = 0.004), and miRNA-93 (β = 0.11, <i>p</i> = 0.04). | 31731799 | 2019 | ||||
|
0.140 | Biomarker | disease | BEFREE | Lentiviral Vector Gene Transfer of Endostatin/Angiostatin for Macular Degeneration (GEM) Study. | 27710144 | 2017 | ||||
|
0.140 | Biomarker | disease | BEFREE | RetinoStat(®) is an equine infectious anemia virus-based lentiviral gene therapy vector that expresses the angiostatic proteins endostatin and angiostatin that is delivered via a subretinal injection for the treatment of the wet form of age-related macular degeneration. | 22716662 | 2012 | ||||
|
0.140 | AlteredExpression | disease | BEFREE | It is not known whether endogenous endostatin at physiological levels has a protective role as an inhibitor of pathological angiogenesis, such as choroidal neovascularization (CNV) in age-related macular degeneration. | 17526870 | 2007 | ||||
|
0.140 | Biomarker | disease | HPO |