Phosphorylation of STAT3 was decreased in the Leu group relative to the control in both mice (<i>p</i> = 0.019) and myotubes (<i>p</i> = 0.02), but did not significantly attenuate the inflammatory effect of LLC implantation (<i>p</i> = 0.619).
We found that the loss of STAT3 in ECs did not affect primary Lewis lung carcinoma (LLC) tumor growth, but it reduced in vivo LLC metastasis in experimental and spontaneous metastasis models.