Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 27031
Gene Symbol: NPHP3
NPHP3 		0.100 Biomarker disease HPO
Entrez Id: 57539
Gene Symbol: WDR35
WDR35 		0.100 Biomarker disease HPO
Entrez Id: 23322
Gene Symbol: RPGRIP1L
RPGRIP1L 		0.100 Biomarker disease HPO
Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4 		0.100 Biomarker disease HPO
Entrez Id: 54903
Gene Symbol: MKS1
MKS1 		0.100 Biomarker disease HPO
Entrez Id: 5428
Gene Symbol: POLG
POLG 		0.100 Biomarker disease HPO
Entrez Id: 5261
Gene Symbol: PHKG2
PHKG2 		0.100 Biomarker disease HPO
Entrez Id: 57545
Gene Symbol: CC2D2A
CC2D2A 		0.100 Biomarker disease HPO
Entrez Id: 51259
Gene Symbol: TMEM216
TMEM216 		0.100 Biomarker disease HPO
Entrez Id: 3295
Gene Symbol: HSD17B4
HSD17B4 		0.100 Biomarker disease HPO
Entrez Id: 51473
Gene Symbol: DCDC2
DCDC2 		0.100 Biomarker disease HPO
Entrez Id: 91147
Gene Symbol: TMEM67
TMEM67 		0.100 Biomarker disease HPO
Entrez Id: 80184
Gene Symbol: CEP290
CEP290 		0.100 Biomarker disease HPO
Entrez Id: 10056
Gene Symbol: FARSB
FARSB 		0.100 Biomarker disease HPO
Entrez Id: 2817
Gene Symbol: GPC1
GPC1 		0.100 Biomarker disease HPO
Entrez Id: 2875
Gene Symbol: GPT
GPT 		0.020 Biomarker disease BEFREE Livers from HRN™ mice exhibited abnormal liver histopathology (enhanced lipid accumulation, bile duct proliferation, hepatocellular degeneration, necrosis, inflammatory cell infiltration) and plasma clinical chemistry (elevated alanine aminotransferase, glutamate dehydrogenase and alkaline phosphatase activities). 30090479 2017
Entrez Id: 1080
Gene Symbol: CFTR
CFTR 		0.010 Biomarker disease BEFREE CFTR is not detected in hepatocytes of normal liver or in livers exhibiting bile duct proliferation. 7504645 1993
Entrez Id: 6696
Gene Symbol: SPP1
SPP1 		0.010 Biomarker disease BEFREE Novel differentially expressed genes in AH in comparison to ND and AS included claudins, osteopontin, CD209, selenoprotein and genes related to bile duct proliferation. 16797773 2006
Entrez Id: 5314
Gene Symbol: PKHD1
PKHD1 		0.010 Biomarker disease BEFREE Pkhd1(del4/del4) mice develop intrahepatic bile duct proliferation with progressive cyst formation and associated periportal fibrosis. 18202188 2008
Entrez Id: 29919
Gene Symbol: RMC1
RMC1 		0.010 Biomarker disease BEFREE I hypothesized, therefore, that MIC-1/GDF-15 may be a mediator of biliary tract injury and could play a role in regulation of bile duct proliferation. 14592665 2003
Entrez Id: 9518
Gene Symbol: GDF15
GDF15 		0.010 Biomarker disease BEFREE I hypothesized, therefore, that MIC-1/GDF-15 may be a mediator of biliary tract injury and could play a role in regulation of bile duct proliferation. 14592665 2003
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.010 Biomarker disease BEFREE Further analysis of these cells revealed colocalized expression of collagen and yes-associated protein (YAP; a marker associated with bile duct proliferation/fibrosis) and an increased production of interleukin-6 and tumor necrosis factor-α. 30471152 2019
Entrez Id: 3949
Gene Symbol: LDLR
LDLR 		0.010 Biomarker disease BEFREE Bile-duct proliferation as an unexpected side-effect after AAV2-LDLR gene transfer to rabbit liver. 31061510 2019
Entrez Id: 151306
Gene Symbol: GPBAR1
GPBAR1 		0.010 Biomarker disease BEFREE Specifically, TCDD elicited a >200-fold increase in taurolithocholic acid (TLCA), a potent G protein-coupled bile acid receptor 1 (GPBAR1) agonist associated with bile duct proliferation. 28725001 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.010 Biomarker disease BEFREE Further analysis of these cells revealed colocalized expression of collagen and yes-associated protein (YAP; a marker associated with bile duct proliferation/fibrosis) and an increased production of interleukin-6 and tumor necrosis factor-α. 30471152 2019