It is noted that the immunohistochemical positivity of MDM2, CDK4, and p16 do not necessarily indicatemalignant neoplasm such as dedifferentiated liposarcoma.
Neuroblastoma is a pediatric cancer with significant genomic and biologic heterogeneity. p16 and ARF, two important tumor-suppressor genes on chromosome 9p21, are inactivated commonly in most cancers, but paradoxically overexpressed in neuroblastoma.