| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | AlteredExpression | disease | BEFREE | RT-PCR confirmed that miR-21 was significantly overexpressed in RCC tissue. | 23558936 | 2013 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | PTENP1 and PTEN are direct targets of miRNA miR21 and their expression is suppressed by miR21 in ccRCC cell lines. miR21 expression promotes ccRCC cell proliferation, migration, invasion in vitro, and tumor growth and metastasis in vivo. | 25249556 | 2014 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | Thus, miR-21 is up-regulated in RCC, and its expression levels can be used as a diagnostic marker to distinguish ccRCC and pRCC from chRCC and oncocytoma. | 22580180 | 2012 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | Our data indicate a clear correlation between miR-21 expression and clinicopathological features and poor prognosis in patients with RCC through the p53/p21-cyclin E2-Bax/caspase-3 signaling pathway. | 28184919 | 2017 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | Relative expression levels of miR-21 in human RCC tissue samples and RCC-derived cell lines were measured using quantitative real-time Polymerase Chain Reaction (PCR). | 29131259 | 2017 | ||||
|
0.100 | Biomarker | disease | BEFREE | The present study provides evidence indicating that CASC2 targeted by miR‑21 acts as a tumor suppressor in RCC. | 27222255 | 2016 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | Decreased expression of SATB1 in ccRCC may result from over-expressed miR-21-5p. | 27107063 | 2017 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | To this end we selected four miRNAs (miR-21-5p, miR-210-3p, miR-185-5p and miR-221-3p) and their expression has been evaluated in a retrospective cohort of formalin-fixed paraffin-embedded (FFPE) tissues from 20 ccRCC patients who underwent surgical nephrectomy resection. miR-21-5p and miR-210-3p resulted the most significantly up-regulated miRNAs in this patient cohort, highlighting these onco-miRNAs as possible relevant players involved in ccRCC tumorigenesis. | 26670229 | 2015 |