Finally, the combination of ATM silencing, radiotherapy, and PD-L1 blockade markedly improves <i>in vivo</i> murine tumor responses, supporting further investigation of this promising approach in pancreatic adenocarcinoma.<i>See related article by Zhang et al., p. 3940</i>.
In conclusion, the results of the present study suggested that suppressing PD-L1 in malignant cells during DC immunization may be a useful tool for immunotherapy in pancreatic adenocarcinoma.