In prostate cancer, however, the expression of AnxA2 is lost in prostate intraepithelial neoplasia and reappears in the high-grade tumors, suggesting a complex regulation of AnxA2 in the prostate microenvironment.
In prostate intraepithelial neoplasiaannexin A2 expression is absent however upon loss of androgen dependence annexin A2 is subsequently over-expressed.