Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 150684
Gene Symbol: COMMD1
COMMD1
0.100 GeneticVariation disease BEFREE In dogs, a mutation in the COMMD1 gene has been found to be associated with copper toxicosis. 24697840 2014
Entrez Id: 150684
Gene Symbol: COMMD1
COMMD1
0.100 Biomarker disease BEFREE This article reviews the work that has been done on the Bedlington terrier, summarizes what was learned from studies into COMMD1 function, describes hereditary copper toxicosis phenotypes in other dog breeds, and discusses the opportunities for genome-wide association studies on copper toxicosis in the dog to contribute to the understanding of mammalian copper metabolism and copper metabolism disorders in man. 22147205 2012
Entrez Id: 150684
Gene Symbol: COMMD1
COMMD1
0.100 Biomarker disease BEFREE ATP7B interacts with COMMD1, a protein that is deleted in Bedlington terriers with hereditary copper toxicosis. 17919502 2007
Entrez Id: 150684
Gene Symbol: COMMD1
COMMD1
0.100 GeneticVariation disease BEFREE A similar form of copper-associated cirrhosis caused by mutations of the canine copper toxicosis MURR1 gene is also observed in Bedlington terriers. 16649058 2006
Entrez Id: 150684
Gene Symbol: COMMD1
COMMD1
0.100 Biomarker disease BEFREE Recently, we characterized the COMMD1 (previously MURR1) gene as the defective gene in canine copper toxicosis. 16267171 2005
Entrez Id: 150684
Gene Symbol: COMMD1
COMMD1
0.100 Biomarker disease BEFREE MURR1, the gene causing canine copper toxicosis in Bedlington terriers, maps to chromosome 2 in humans, a region different to the Wilson gene locus. 15205742 2004
Entrez Id: 150684
Gene Symbol: COMMD1
COMMD1
0.100 GeneticVariation disease BEFREE MURR1 is mutated in canine Cu toxicosis, a disorder with phenotypic characteristics similar to those of Wilson disease. 15099406 2004
Entrez Id: 150684
Gene Symbol: COMMD1
COMMD1
0.100 GeneticVariation disease BEFREE The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis. 12547404 2003
Entrez Id: 150684
Gene Symbol: COMMD1
COMMD1
0.100 AlteredExpression disease BEFREE The ubiquitously expressed MURR1 protein is absent in canine copper toxicosis. 14568250 2003
Entrez Id: 150684
Gene Symbol: COMMD1
COMMD1
0.100 GeneticVariation disease BEFREE Although the function of the MURR1 gene is still unknown, the discovery of a mutated MURR1 gene in Bedlington terriers with copper toxicosis provides a new lead to disentangling the complexities of copper metabolism in mammals. 11809725 2002