Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.200 Biomarker disease HPO
Entrez Id: 4137
Gene Symbol: MAPT
MAPT 		0.200 Biomarker disease HPO
Entrez Id: 5621
Gene Symbol: PRNP
PRNP 		0.200 Biomarker disease HPO
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		0.200 Biomarker disease HPO
Entrez Id: 54209
Gene Symbol: TREM2
TREM2 		0.130 Biomarker disease HPO
Entrez Id: 5664
Gene Symbol: PSEN2
PSEN2 		0.120 Biomarker disease HPO
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7 		0.110 Biomarker disease HPO
Entrez Id: 2896
Gene Symbol: GRN
GRN 		0.110 Biomarker disease HPO
Entrez Id: 25978
Gene Symbol: CHMP2B
CHMP2B 		0.100 Biomarker disease HPO
Entrez Id: 7415
Gene Symbol: VCP
VCP 		0.100 Biomarker disease HPO
Entrez Id: 203228
Gene Symbol: C9orf72
C9orf72 		0.100 Biomarker disease HPO
Entrez Id: 54664
Gene Symbol: TMEM106B
TMEM106B 		0.100 Biomarker disease HPO
Entrez Id: 7276
Gene Symbol: TTR
TTR 		0.020 Biomarker disease BEFREE Indeed, it is likely that prealbumin is the major constituent of amyloid associated with neuritic plaque, neurofibrillary tangle, and microangiopathy. 6950666 1982
Entrez Id: 2670
Gene Symbol: GFAP
GFAP 		0.070 AlteredExpression disease BEFREE In AD, the latter pattern predominates, consistent with induction of GFAP mRNA in the sites of synthesis in glial processes in the neuritic plaque. 3507557 1987
Entrez Id: 351
Gene Symbol: APP
APP 		0.400 Biomarker disease BEFREE Unexpectedly, the antibodies to the carboxyl terminus of beta APP labeled amyloid-containing senile plaques in AD brain. 3140239 1988
Entrez Id: 351
Gene Symbol: APP
APP 		0.400 Biomarker disease BEFREE The regulation of extracellular proteolysis by PN-II and the deposition of at least parts of the molecule in senile plaques is consistent with previous reports that implicate altered proteolysis in the pathogenesis of Alzheimer's disease. 2507928 1989
Entrez Id: 351
Gene Symbol: APP
APP 		0.400 Biomarker disease BEFREE The beta-amyloid protein (beta/A4), derived from a larger amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease. 1691865 1990
Entrez Id: 351
Gene Symbol: APP
APP 		0.400 Biomarker disease BEFREE The beta-amyloid peptide is a core component of the neuritic plaques that accumulate in Alzheimer's disease. 2115911 1990
Entrez Id: 5621
Gene Symbol: PRNP
PRNP 		0.200 Biomarker disease BEFREE Some transgenic (Tg) mouse (Mo) lines that carry and express a Syrian hamster (Ha) PrP gene developed scrapie 75 d after inoculation with Ha prions; non-Tg mice failed to show symptoms after greater than 500 d. Brains of these infected Tg(HaPrP) mice featured protease-resistant HaPrPSc, amyloid plaques characteristic for Ha scrapie, and 10(9) ID50 units of Ha-specific prions upon bioassay. 1684745 1991
Entrez Id: 351
Gene Symbol: APP
APP 		0.400 Biomarker disease BEFREE It is known that beta APP accumulates in the neuritic plaques and cerebrovascular deposits of patients with Alzheimer's disease. 1593645 1992
Entrez Id: 351
Gene Symbol: APP
APP 		0.400 Biomarker disease BEFREE Apolipoprotein E (APO-E) binds to the beta-amyloid peptide and is present in senile neuritic plaques in Alzheimer's disease (AD). 8239575 1993
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.200 Biomarker disease BEFREE Apolipoprotein E (apoE) is associated with Alzheimer's neurofibrillary tangles and beta-amyloid protein in senile plaques. 8103819 1993
Entrez Id: 5621
Gene Symbol: PRNP
PRNP 		0.200 Biomarker disease BEFREE Neuritic plaques characteristic of AD were once thought to be exclusively associated with beta-A4 amyloid; however, some pedigrees with familial prion disease produced neuritic plaques with PrP amyloid cores. 7904883 1993
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.200 Biomarker disease BEFREE In vitro, apolipoprotein E in cerebrospinal fluid binds to synthetic beta A4 peptide (the primary constituent of the senile plaque) with high avidity. 8446617 1993
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.200 Biomarker disease BEFREE Apolipoprotein E (APO-E) binds to the beta-amyloid peptide and is present in senile neuritic plaques in Alzheimer's disease (AD). 8239575 1993