Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.510 CausalMutation disease CGI
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 CausalMutation disease CLINVAR
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 CausalMutation disease CGI
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Results suggested that aberrations of the p53 gene were not correlated with the malignancy of some types of brain tumors such as anaplastic astrocytoma and glioblastoma, contrary to previous observations on colorectal cancers. 1886708 1991
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Five of the 11 grade III astrocytomas (glioblastoma multiforme), but only one of seven grade II astrocytomas (anaplastic astrocytoma) and none of either the grade I astrocytomas or oligodendrogliomas demonstrated distinct point mutations involving the TP53 gene. 1686725 1991
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Loss of heterozygosity (LOH) was determined by Southern transfer analysis of somatic and tumor DNA from these same patients using polymorphic markers for various loci on chromosomes 10 and 17. p53 mutations were found in 7 of 25 glioblastomas (28%), in 5 of 14 anaplastic astrocytomas (36%) but in 0 of 6 low-grade astrocytomas. p53 mutations were found in 62% of patients with LOH on chromosome 17p. 1346255 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE The more malignant histological features of anaplastic astrocytoma and glioblastoma multiforme appear to be reflected by a greater incidence of p53 accumulation. 1336544 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Human malignant gliomas (glioblastomas and anaplastic astrocytomas) are the most frequent brain tumors and are associated with a variety of genetic alterations including retinoblastoma (RB) and p53 gene mutations, loss of interferon alpha and beta (IFNA, IFNB) genes and lack of O6-methylguanine-DNA methyltransferase (MGMT) expression. 1501894 1992
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.100 GeneticVariation disease BEFREE Human malignant gliomas (glioblastomas and anaplastic astrocytomas) are the most frequent brain tumors and are associated with a variety of genetic alterations including retinoblastoma (RB) and p53 gene mutations, loss of interferon alpha and beta (IFNA, IFNB) genes and lack of O6-methylguanine-DNA methyltransferase (MGMT) expression. 1501894 1992
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker disease BEFREE We observed EGFR gene amplification in astrocytomas and anaplastic astrocytomas with approximately the same incidence as in glioblastoma multiforme (33%), although large amplifications were only seen in glioblastoma multiforme. 1311022 1992
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.030 GeneticVariation disease BEFREE Human malignant gliomas (glioblastomas and anaplastic astrocytomas) are the most frequent brain tumors and are associated with a variety of genetic alterations including retinoblastoma (RB) and p53 gene mutations, loss of interferon alpha and beta (IFNA, IFNB) genes and lack of O6-methylguanine-DNA methyltransferase (MGMT) expression. 1501894 1992
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.010 AlteredExpression disease BEFREE In addition to the cultured cells, we examined IL-8 gene expression within human malignant astrocytoma, peritumoral brain and autopsied normal brains. 1407609 1992
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
0.010 AlteredExpression disease BEFREE To investigate whether endothelial cells become activated during tumorigenesis and progression of human gliomas by a platelet-derived growth factor (PDGF) dependent pathway, we analyzed platelet-derived growth factor receptor-beta (PDGFR-beta) expression by in situ hybridization and immunocytochemistry in normal human brain, astrocytoma (grade II), anaplastic oligo-astrocytoma (grade III), and glioblastoma multiforme (grade IV). 1434531 1992
Entrez Id: 302
Gene Symbol: ANXA2
ANXA2
0.010 AlteredExpression disease BEFREE In experiments to identify molecules that might be important in the pathogenesis of glioblastoma multiforme, the most common malignant brain tumor, we found that annexin II (Lipocortin 2, p36), a likely second messenger in several different mitogenic pathways, was highly expressed in tumor tissue of glioblastoma multiforme (9 of 9) and highly anaplastic astrocytoma (2 of 6), but not in astrocytomas of lower pathological grade (0 of 6). 1333884 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 PosttranslationalModification disease BEFREE These data suggest that alterations of the p53 gene may play an important role in the genesis of malignant astrocytoma. 7904621 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Six astrocytic tumors (one anaplastic astrocytoma and five glioblastoma multiforme) were found to have putative p53 mutations. 7903434 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE An additional 10 cases (i.e., 3 anaplastic astrocytomas and 7 meningiomas) were found to be p53 protein positive with the DO-7 mAb. 8337939 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE These and published data support the view that p53 mutations are frequently involved both in low-grade and progressive (anaplastic) astrocytomas, including glioblastomas multiforme. 8397797 1993
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.040 AlteredExpression disease BEFREE We studied a series of 157 primary brain tumors and report here that the MDM2 gene is amplified and overexpressed in 8-10% of glioblastomas and anaplastic astrocytomas. 8504413 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE The single strand conformation polymorphism (SSCP) assay of exons 2-11 of the p53 gene and direct DNA sequencing identified p53 mutations in 14% (one of seven) of grade I, 25% (two of eight) of grade II, and 19% (three of 16) of grade III astrocytomas. 8108140 1994
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Using a monoclonal antibody that reacts with both mutant and wild-type p53 protein (PAb 1801), reactivity was assessed immunohistochemically in specimens from the first diagnosis of astrocytic neoplasm in 95 patients: 26 astrocytomas (A), 19 anaplastic astrocytomas (AA), and 50 glioblastomas multiforme (GBM). 7866633 1994
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE There was also an increased incidence of TP53 mutation in patients with anaplastic astrocytoma histology. 8118823 1994
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE A human pilocytic astrocytoma-derived cell line, a grade III astrocytoma-derived cell line, and a glioblastoma-derived cell line were transfected with the human wild-type p53 gene, in order to demonstrate the possible suppressor role of this gene in low grade as well as in high grade human astrocytomas. p53 exhibited a strong growth suppressor effect on the three cell lines studied, irrespective of the grade of malignancy of the tumours from which they originate. 7707071 1994
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker disease BEFREE Allele loss on chromosomes 10 and 17p and epidermal growth factor receptor gene amplification in human malignant astrocytoma related to prognosis. 7917918 1994
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 GeneticVariation disease BEFREE Amplification of the CDK4 gene was present in 7 of 14 (50%) glioblastomas and 3 of 11 (27%) anaplastic astrocytomas with no losses at the CDKN2 locus as well as in 2 of 32 (6%) glioblastomas with CDKN2 losses. 7987821 1994