×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
Biomarker
disease
BEFREE
Serum Makorin ring finger protein 3 values for predicting Central precocious puberty in girls.
30806524
2019
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
GeneticVariation
disease
BEFREE
Paternally-inherited loss-of-function mutations in makorin ring finger protein 3 gene (<i>MKRN3</i>) underlie central precocious puberty .
30800097
2019
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
GeneticVariation
disease
BEFREE
Outcomes of Patients with Central Precocious Puberty due to Loss-of-Function Mutations in MKRN3 Gene After Treatment with Gonadotropin-Releasing Hormone Analog.
31671431
2019
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
GeneticVariation
disease
BEFREE
Low Frequency of MKRN3 and DLK1 Variants in Chinese Children with Central Precocious Puberty .
31687022
2019
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
GeneticVariation
disease
BEFREE
Investigation of MKRN3 Mutation in Patients with Familial Central Precocious Puberty
29537379
2018
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
GeneticVariation
disease
BEFREE
Loss-of-function mutations in the coding region of MKRN3 , a maternally imprinted gene at chromosome 15q11.2, are a common cause of familial central precocious puberty (CPP).
29763903
2018
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
AlteredExpression
disease
BEFREE
MKRN3 levels were lower in patients with central precocious puberty compared to prepubertal age-matched ones (p: 0.0004) and comparable to those matched for pubertal stage.
28299573
2018
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
Biomarker
disease
BEFREE
MKRN3 Levels in Girls with Central Precocious Puberty during GnRHa Treatment: A Longitudinal Study.
30269125
2018
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
GeneticVariation
disease
BEFREE
High Frequency of MKRN3 Mutations in Male Central Precocious Puberty Previously Classified as Idiopathic.
27225315
2017
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
GeneticVariation
disease
BEFREE
Two Frameshift Mutations in MKRN3 in Turkish Patients with Familial Central Precocious Puberty .
27798941
2017
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
GeneticVariation
disease
BEFREE
Low Frequency of MKRN3 Mutations in Central Precocious Puberty Among Korean Girls.
25938887
2016
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
GeneticVariation
disease
BEFREE
Ten girls with sporadic central precocious puberty were screened for mutations in the maternally imprinted gene MKRN3 .
27640350
2016
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
GeneticVariation
disease
BEFREE
Loss-of-function mutations in the imprinted gene MKRN3 represent the most common known genetic defects associated with central precocious puberty (CPP).
27424312
2016
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
GeneticVariation
disease
BEFREE
In silico analysis of a novel MKRN3 missense mutation in familial central precocious puberty .
26173472
2016
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
GeneticVariation
disease
BEFREE
Mutations in the maternally imprinted gene MKRN3 are common in familial central precocious puberty .
26431553
2016
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
GeneticVariation
disease
BEFREE
The role of MKRN3 , an imprinted gene located in the Prader-Willi syndrome critical region (chromosome 15q11-13), in pubertal initiation was first described in 2013 after the identification of deleterious MKRN3 mutations in five families with central precocious puberty (CPP) using whole-exome sequencing analysis.
25957321
2015
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
GeneticVariation
disease
BEFREE
A missense mutation in MKRN3 in a Danish girl with central precocious puberty and her brother with early puberty.
26331766
2015
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
GeneticVariation
disease
BEFREE
MKRN3 mutations in familial central precocious puberty .
25011910
2014
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
GeneticVariation
disease
BEFREE
In this report we describe a family with central precocious puberty associated with a mutation in the makorin RING-finger protein 3 (MKRN3 ) gene.
25316453
2014
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
AlteredExpression
disease
BEFREE
Recent human studies implicated the activation of kisspeptin and its cognate receptor (KISS1/KISS1R) and the inactivation of MKRN3 in the premature reactivation of GnRH secretion, causing central precocious puberty (CPP).
25116033
2014
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
Biomarker
disease
BEFREE
Deficiency of MKRN3 causes central precocious puberty in humans.
23738509
2013
×
Entrez Id:
7681
Gene Symbol:
MKRN3
MKRN3
0.400
Biomarker
disease
CTD_human
Deficiency of MKRN3 causes central precocious puberty in humans.
23738509
2013