| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | The role of IL-17 and IL-17 receptor inhibitors in the management of generalized pustular psoriasis. | 31584575 | 2019 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Successful treatment with interleukin-17A antagonists of generalized pustular psoriasis in patients without IL36RN mutations. | 29655177 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | We ascertained a total of 101 published cases according to our predefined criteria and identified TNF-α, IL-12/23, IL-17 and IL-1β as targets for immunotherapy for the treatment of GPP. | 29852521 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | The aim of this open-label study was to evaluate the long-term efficacy and safety of ixekizumab, a humanized, anti-interleukin-17A monoclonal antibody, in Japanese patients with plaque psoriasis (n = 78, including 11 psoriatic arthritis), erythrodermic psoriasis (n = 8) and generalized pustular psoriasis (n = 5). | 27726163 | 2017 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We detected significant contributions of IL-17A, TNF, IL-1, IL-36, and interferons in both diseases; although GPP lesions furnished higher IL-1 and IL-36 and lower IL-17A and IFN-γ mRNA expression than PV lesions did. | 28043870 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | However, the pathological roles of IL-17 cascades in generalized pustular psoriasis (GPP) and psoriatic erythroderma (PsE) have not been well established. | 27106510 | 2017 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Here we show that IL-17A/F is highly expressed by innate immune cells such as neutrophils and mast cells in both AGEP and GPP. | 25030504 | 2014 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Patients with palmoplantar pustulosis have increased IL-17 and IL-22 levels both in the lesion and serum. | 21732985 | 2011 |