| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.360 | Biomarker | disease | BEFREE | The significance of interleukin 24 (IL24) and its receptors in pancreatic cancer were investigated in this study. | 26977011 | 2016 | ||||
|
0.360 | Biomarker | disease | BEFREE | Unfortunately, mda-7/IL-24 application in pancreatic cancer has been restricted because of a "translational block" occurring after Ad.5-mda-7 gene delivery. | 25452327 | 2015 | ||||
|
0.360 | Biomarker | disease | BEFREE | Because both POH and Ad.mda-7 are being evaluated in clinical trials, combining a dietary agent and a virally delivered therapeutic cytokine provides an innovative approach for potentially treating human pancreatic cancer. | 18768668 | 2008 | ||||
|
0.360 | Biomarker | disease | BEFREE | The recombinant adenovirus AdGFP/IL-24 can effectively express biologically active human interleukin-24, which results in inhibition of pancreatic cancer growth. | 19080270 | 2008 | ||||
|
0.360 | Therapeutic | disease | CTD_human | In pancreatic cancer cells constitutively expressing mda-7/IL-24 mRNA, a single treatment with arsenic trioxide, HPR or NSC656240 induces apoptosis, which correlates with production of MDA-7/IL-24 protein. | 15580305 | 2005 | ||||
|
0.360 | Biomarker | disease | BEFREE | Analysis of signal transduction changes in pancreatic carcinoma cells infected with Ad.mda-7 in combination with a ROS-inducer indicate that cell death correlates with modulation of discrete cassettes of multiple signaling pathways in a pancreatic cancer cell-specific manner, supporting global signaling dysregulation as a potential mediator of apoptosis induction. | 15580305 | 2005 | ||||
|
0.360 | Biomarker | disease | BEFREE | In sum, we show that Ad-mda7 is able to induce growth inhibition and apoptosis in pancreatic cancer cells via inhibition of the Wnt/PI3K pathways and identify a novel bystander mechanism of MDA-7 killing in pancreatic cancer that functions via IL-20 receptors. | 15851011 | 2005 |