| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.380 | AlteredExpression | disease | BEFREE | Furthermore, HK1, PKLR, and LDHA expression correlated positively with PC progression. | 31689601 | 2020 | ||||
|
0.380 | Biomarker | disease | BEFREE | The targeting of glycolytic enzymes such as PKM2 and LDHA represents a promising therapeutic approach for the treatment of pancreatic cancer. | 31527446 | 2019 | ||||
|
0.380 | Biomarker | disease | CTD_human | MTOR inhibitor-based combination therapies for pancreatic cancer. | 29384525 | 2018 | ||||
|
0.380 | Biomarker | disease | BEFREE | Taken together, our findings highlight p53 status in pancreatic cancer as a biomarker to predict sensitivity to LDH-A inhibition, with regard to both real-time noninvasive imaging by 13C MRS as well as therapeutic response. | 26113084 | 2015 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | In this study, we found that c-Myc and LDHA are concomitantly overexpressed in pancreatic cancer cell lines and clinical specimens. c-Myc overexpression and LDHA overexpression were correlated with TNM stage and tumor size and indicated poor prognosis in patients with pancreatic cancer. | 26021472 | 2015 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression. | 24634381 | 2014 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | We found a negative correlation between KLF4 and LDHA expression in pancreatic cancer cells and tissues and that their expression was associated with clinicopathologic features of pancreatic cancer. | 24947925 | 2014 | ||||
|
0.380 | Biomarker | disease | BEFREE | Taken together, our study revealed the oncogenic role of LDHA in pancreatic cancer and suggested that LDHA might be a potential therapeutic target. | 23404405 | 2013 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | Our study reveals a mechanism of LDH-A upregulation in pancreatic cancers. | 23523103 | 2013 |