Source: ALL
| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | AlteredExpression | disease | BEFREE | Combined CagA, p-SHP-2, and p-ERK expression showed an increased positive predictive value (81.8% vs 75.9%) and an increased specificity (84.0% vs 75.0%) for HP dependence compared with CagA expression alone. | 27864293 | 2017 | ||||
|
0.090 | Biomarker | disease | BEFREE | Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins. | 28930683 | 2017 | ||||
|
0.090 | Biomarker | disease | BEFREE | Because to date there is no available study on STAT3 polymorphism and gastric cancer in Western populations and taking into account that Helicobacter pylori CagA EPIYA-C segment deregulates SHP-2/ERK-JAK/STAT3 pathways, we evaluated whether the two variables are independently associated with gastric cancer. | 26186918 | 2015 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | This study aimed to demonstrate the tyrosine phosphorylation motif (TPM) and 3' region structure of the Helicobacter pylori CagA gene as well as its SHP-2 binding activity in AGS cells and relation to gastric carcinogenesis. | 23464450 | 2012 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Association of polymorphism of PTPN 11 encoding SHP-2 with gastric atrophy but not gastric cancer in Helicobacter pylori seropositive Chinese population. | 22788847 | 2012 | ||||
|
0.090 | Biomarker | disease | BEFREE | Src homology 2 domain-containing protein tyrosine phosphatase-2 (SHP-2) of gastric epithelial cells interacts with cagA from Helicobacter pylori (H. pylori). | 18712962 | 2009 | ||||
|
0.090 | Biomarker | disease | BEFREE | Host cytokine gene polymorphisms and a frequent single nucleotide polymorphism in the PTPN11 gene that encodes SHP-2 may associate with gastric atrophy among Helicobacter pylori-infected subjects. | 17323188 | 2007 | ||||
|
0.090 | Biomarker | disease | BEFREE | Association between serum pepsinogens and polymorphismof PTPN11 encoding SHP-2 among Helicobacter pylori seropositive Japanese. | 16032704 | 2006 | ||||
|
0.090 | Biomarker | disease | BEFREE | In addition, Shp2 might be a key virulence determinant for the important human pathogen Helicobacter pylori. | 12826400 | 2003 |