Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | AlteredExpression | disease | BEFREE | LAL activity measured in liver biopsies from NAFLD patients was highly correlated to that measured on DBS and was independent of LAL expression in the liver. | 31505261 | 2019 | ||||
|
0.100 | Biomarker | disease | BEFREE | It has been suggested that CESD may affect 1 in 40,000 and is under-diagnosed in NAFLD clinics. | 30315827 | 2019 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | The low activity of lysosomal acid lipase (LAL) could be involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), which is a common feature in morbidly obese patients. | 31067824 | 2019 | ||||
|
0.100 | Biomarker | disease | BEFREE | LAL-D is a rare disease that can appear similar to NAFLD in adults. | 31582009 | 2019 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | Lysosomal acid lipase activity and liver fibrosis in the clinical continuum of non-alcoholic fatty liver disease. | 31392821 | 2019 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | These findings suggest that the modulation of LAL activity may become a possible new therapeutic target for patients with more advanced forms of NAFLD. | 31435171 | 2019 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | LAL activity is significantly reduced in NAFLD, compared to that in HCV patients. | 28587063 | 2017 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | We investigate the association between spleen dimensions and LAL activity in non-alcoholic fatty liver disease (NAFLD) patients, in whom a reduced LAL activity has been reported. | 28900817 | 2017 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | So far, very few studies have been performed to assess LAL activity in representative samples of normal subjects or patients with NAFLD. | 26602919 | 2015 | ||||
|
0.100 | Biomarker | disease | BEFREE | Human studies employed cohorts of LAL-deficient patients and NAFLD subjects. | 23624251 | 2013 |