Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23268
Gene Symbol: DNMBP
DNMBP 		0.030 Biomarker disease BEFREE Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. 16740596 2006
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.350 GeneticVariation disease BEFREE Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease. 16908746 2006
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.400 GeneticVariation disease BEFREE Apolipoprotein E (ApoE) genotype, the major genetic risk factor in sporadic late-onset Alzheimer Disease (AD), modulates cerebral perfusion in late middle-age cognitively normal subjects. 16930470 2006
Entrez Id: 347731
Gene Symbol: LRRTM3
LRRTM3 		0.040 Biomarker disease BEFREE LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease. 17098871 2006
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.400 Biomarker disease BEFREE APOE is the only confirmed susceptibility gene for LOAD.Others remain yet to be found. 17373700 2007
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		0.400 GeneticVariation disease BEFREE Presenilin-1 2/2 genotype is a risk factor for late onset Alzheimer disease in the Spanish population, and probably, for Europeans. 17719017 2007
Entrez Id: 1785
Gene Symbol: DNM2
DNM2 		0.020 Biomarker disease BEFREE Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers. 18236001 2008
Entrez Id: 27306
Gene Symbol: HPGDS
HPGDS 		0.030 GeneticVariation disease BEFREE Glutathione S-transferase variants increase susceptibility for late-onset Alzheimer's disease: association study and relationship with apolipoprotein E epsilon4 allele. 18298341 2008
Entrez Id: 9846
Gene Symbol: GAB2
GAB2 		0.100 Biomarker disease BEFREE GAB2 may not be a disease susceptibility gene for LOAD in Japanese. 18854865 2009
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2 		0.330 Biomarker disease BEFREE PVRL2, TOMM40 and APOC1, could also yield a predisposition to LOAD. 19442637 2009
Entrez Id: 255022
Gene Symbol: CALHM1
CALHM1 		0.070 GeneticVariation disease BEFREE CALHM1 polymorphism is not associated with late-onset Alzheimer disease. 19472444 2009
Entrez Id: 255022
Gene Symbol: CALHM1
CALHM1 		0.070 GeneticVariation disease BEFREE CALHM1 P86L polymorphism is associated with late-onset Alzheimer's disease in a recessive model. 20164592 2010
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.400 GeneticVariation disease BEFREE APOE allele (∗)3, the most frequent variant, is not associated to cognitive dysfunction (CD) or to increased AD risk. 20406267 2010
Entrez Id: 1378
Gene Symbol: CR1
CR1 		0.350 GeneticVariation disease BEFREE Complement receptor 1 polymorphisms and risk of late-onset Alzheimer's disease. 20558149 2010
Entrez Id: 2597
Gene Symbol: GAPDH
GAPDH 		0.030 Biomarker disease BEFREE Glyceraldehyde-3-phosphate dehydrogenase gene (GAPDH) and its paralogs were implicated in late-onset Alzheimer's disease (LOAD), although the strength and direction of association have not been consistent. 20864222 2012
Entrez Id: 7019
Gene Symbol: TFAM
TFAM 		0.330 GeneticVariation disease BEFREE Mitochondrial transcription factor A (TFAM) polymorphisms and risk of late-onset Alzheimer's disease in Han Chinese. 20977898 2011
Entrez Id: 351
Gene Symbol: APP
APP 		0.400 GeneticVariation disease BEFREE Amyloid precursor protein gene (APP) variation in late-onset Alzheimer's disease. 21424791 2011
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.400 Biomarker disease BEFREE Apo E is the major component of lipoprotein particles in the brain that mediate transport of cholesterol and other lipids between neurons and glial cells, indicating an implication of cerebral lipid metabolism in the pathogenesis of AD. 21605030 2012
Entrez Id: 7097
Gene Symbol: TLR2
TLR2 		0.030 GeneticVariation disease BEFREE TLR2 gene might not play a major role in the genetic predisposition to late-onset Alzheimer's disease in this population. 21621299 2011
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.400 GeneticVariation disease BEFREE Apolipoprotein E genotypes and neuropsychiatric symptoms and syndromes in late-onset Alzheimer's disease. 21763789 2012
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.400 GeneticVariation disease BEFREE Apolipoprotein E (APOE) genotypes are associated with variable risk of developing late-onset Alzheimer's disease (LOAD), with APOE epsilon 4 (APOE ε4) having higher risk. 21784354 2011
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP 		0.010 Biomarker disease BEFREE TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosis and clinical phenotype. 21968532 2011
Entrez Id: 9446
Gene Symbol: GSTO1
GSTO1 		0.020 GeneticVariation disease BEFREE GSTO1*E155del polymorphism associated with increased risk for late-onset Alzheimer's disease: association hypothesis for an uncommon genetic variant. 22100662 2012
Entrez Id: 5300
Gene Symbol: PIN1
PIN1 		0.030 Biomarker disease BEFREE Pin1 contribution to Alzheimer's disease: transcriptional and epigenetic mechanisms in patients with late-onset Alzheimer's disease. 22261503 2012
Entrez Id: 1789
Gene Symbol: DNMT3B
DNMT3B 		0.020 GeneticVariation disease BEFREE DNMT3B promoter polymorphisms and risk of late onset Alzheimer's disease. 22272627 2012