Gene: ACE ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 GeneticVariation disease BEFREE CONCLUSIONS D allele and DD genotype of ACE gene are possible genetic markers for the risk of LVH in Uighur but not Han hypertension-OSAHS patients. 31064975 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 Biomarker disease BEFREE Other potential causes include angiotensin-converting enzyme inhibitor use, environmental triggers, tobacco use, chronic obstructive pulmonary disease, and obstructive sleep apnea. 29094873 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 GeneticVariation disease BEFREE Our study demonstrated that TNF-α 308 G/A, 5-HTT LPR, and 5-HTT-VNTR polymorphisms were associated with OSAS risk, whereas little association was observed between 5-HTR2A 102C/T, 5-HTR2A A1438G, ACE I/D, or LEPR-Gln 223Arg polymorphism and risk of OSAS in the Chinese population. 25917830 2015
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 AlteredExpression disease BEFREE Collectively, genetically-reduced serum ACE activity might be a causal risk factor for OSAS. 26486181 2015
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 GeneticVariation disease BEFREE ACE polymorphism I/D had no statistically significant association with increased OSA risk, but the II genotype of ACE may be a risk factor for OSA with hypertension in Asians. 24271410 2014
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 Biomarker disease RGD Atrial fibrosis in a chronic murine model of obstructive sleep apnea: mechanisms and prevention by mesenchymal stem cells. 24775918 2014
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 Biomarker disease BEFREE We also found that there was no significant association between ACE I/D and OSAHS severity risk.No publication biases were observed. 23359027 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 Biomarker disease BEFREE The frequencies of II genotype (OR = 1.8, 95 % CI 1.26-2.60, p = 0.001) and I allele (OR = 1.4, 95 % CI 1.13-1.69, p = 0.001) of ACE gene were found to be significantly increased in patients with OSA as compared to patients without OSA. 23371888 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 GeneticVariation disease BEFREE We aimed to undertake a meta-analysis of existing studies exploring the association of ACE I/D polymorphisms with the risk of OSA and hypertension. 22183487 2012
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 GeneticVariation disease BEFREE We conclude that ACE I/D gene polymorphism is not a genetic risk factor for OSAS in Turkish patients. 20449805 2010
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 GeneticVariation disease BEFREE Our results suggest that II and ID genotypes of the ACE gene increase the risk of developing OSAS in the Turkish population. 20182789 2010
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 GeneticVariation disease BEFREE We therefore tested the hypothesis that ACE polymorphism influences OSA severity. 19482546 2009
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 GeneticVariation disease BEFREE An interaction analysis including sex, ACE I/D polymorphism (DD and ID versus II), and OSA identified a significant interaction between OSA and the ACE I/D polymorphism: odds ratio (OR) 6.3, 95% confidence interval (CI) 1.8-22.5, P = 0.004 as well as between OSA and sex: OR 3.3, 95% CI 1.1-9.6, P = 0.033. 17351369 2007
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 GeneticVariation disease BEFREE The ACE deletion allele may protect against hypertension in the setting of obstructive sleep apnea. 17520798 2007
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 GeneticVariation disease LHGDN The association of angiotensin converting enzyme (ACE) polymorphisms with sleep apnea and hypertension. 17520798 2007
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 AlteredExpression disease BEFREE ACE activity was higher in OSAS patients (53.9+/-2.5 IU.L(-1)) than in healthy controls (42.4+/-3.1 IU.L(-1), p<0.01). 11401071 2001
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 GeneticVariation disease BEFREE The distribution of ACE gene I/D allele and genotypes were analyzed in the subject population, as was an OSA pedigree. 11016793 2000
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.300 GeneticVariation disease BEFREE Angiotensin I-converting enzyme gene polymorphism in Chinese patients with obstructive sleep apnea syndrome. 11601275 1999