Gene: CLOCK ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 Biomarker disease BEFREE Core clock genes (CCG) and its controlled genes disruption is implicated in the progression of metabolic syndrome. 31351068 2019
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 AlteredExpression disease BEFREE Looking at clock genes, however, there is no obvious association between symptoms of diabetes or metabolic syndrome and clock gene expression. 29730779 2018
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 Biomarker disease BEFREE Metabolic homeostasis is linked to the circadian clock (rhythm), with multiple signaling pathways in organs regulated by circadian clock genes, and recent studies of circadian clock gene functions suggest that disruption of the circadian rhythm is associated with significant morbidity and mortality, including the metabolic syndrome. 30121811 2018
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE Our data showed a nominal association of MetS with several single nucleotide polymorphisms (SNPs) in five key circadian clock genes including ARNTL, GSK3B, PER3, RORA, and RORB; but none of these SNPs persisted significantly after performing Bonferroni correction. 28296937 2017
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 Biomarker disease BEFREE The circadian clock affects metabolic cycles, and there is a link between circadian clock genes and metabolic syndrome. 25391456 2015
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE Our data support the notion that a chronic consumption of a healthy diet may play a contributing role in triggering glucose metabolism by interacting with the rs1801260 SNP at CLOCK gene locus in MetS patients. 24328727 2014
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE The aim of this research was to investigate the influence of obesity and metabolic syndrome (MetS) features in clock gene methylation and the involvement of these epigenetic modifications in the outcomes. 23003921 2012
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE Genetic variants of Period 2 (PER2), a circadian clock gene, have been linked to metabolic syndrome (MetS). 22623394 2012
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE Thus, the aim of the present study was to determine whether the development of menopause induces an alteration of the genes that control biological rhythms in human subcutaneous (SAT) and visceral (VAT) adipose tissue, and whether changes in clock gene expression are involved in the increased risk of developing metabolic syndrome (MetS), which is frequently associated with menopause. 21898035 2012
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE A significant interaction between the 5-HTTLPR variant and the haplotype rs1554483-rs4864548 of the CLOCK gene was detected for diastolic (p = .0058) and systolic blood pressure (p = .0014), arterial hypertension (p = .033), plasma triglycerides levels (p = .033), and number of MS components (p = .01). 20653450 2010
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE Current studies are illustrating the particular role of different clock gene variants and their predicted haplotypes in MetS. 19276891 2009
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids. 19846548 2009
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 GeneticVariation disease BEFREE These findings suggest that the Clock gene CGC haplotype may be protective for the development of obesity and support the hypothesis that genetic variation in the Clock gene may play a role in the development of the metabolic syndrome, type 2 diabetes and cardiovascular disease. 18071340 2008
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.100 Biomarker disease BEFREE A second objective was to elucidate whether these clock genes expressions were related to the metabolic syndrome features. 17653067 2008