| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | group | BEFREE | Our study suggests that ERK inhibition may be a neuroprotective target against acrolein-induced neuroinflammation in the CNS neurodegenerative diseases. | 31786775 | 2020 | ||||
|
0.070 | Biomarker | group | BEFREE | The Role of PI3K/Akt and ERK in Neurodegenerative Disorders. | 30707354 | 2019 | ||||
|
0.070 | Biomarker | group | BEFREE | Our findings indicate that cell-permeable p38 protein may be useful in preventing the degeneration of higher brain function occurring through hippocampal neuronal cell death, and furthermore, that the maintenance of intracellular p38 levels could be another therapeutic target for neurodegenerative diseases such as Alzheimer's disease (AD). | 30735722 | 2019 | ||||
|
0.070 | Biomarker | group | BEFREE | Considering the proinflammatory roles of p38 MAPK, its inhibitors can be potential therapeutic agents for neurodegenerative diseases relating to neuroinflammation initiated by microglia activation. | 30327995 | 2018 | ||||
|
0.070 | Biomarker | group | BEFREE | Modulation of transcription, transduction, intracellular signaling pathways including ERK, p38, and MAPK, with upstream regulatory activity on inflammatory cascades, apoptosis and oxidative stress associated pathways, play an essential role in the preventive and therapeutic potential of the plants in neurodegenerative diseases. | 29512453 | 2018 | ||||
|
0.070 | GeneticVariation | group | BEFREE | Late-onset neurodegenerative disease observed in patients with histiocytoses, which are clonal myeloid diseases associated with somatic mutations in the RAS-MEK-ERK pathway such as BRAF(V600E), suggests a possible role of somatic mutations in myeloid cells in neurodegeneration. | 28854169 | 2017 | ||||
|
0.070 | Biomarker | group | BEFREE | This research highlights new bioactivities for gracilins, such as BACE1 and ERK inhibition, and provides more evidence for their potential therapeutic application in neurodegenerative diseases due to their multi-target activities, especially in AD. | 25724081 | 2015 |