Here, we have applied RC-seq and whole-genome sequencing (WGS) to an <i>Abcb4 (Mdr2)</i><sup>-/-</sup> mouse model of hepatic carcinogenesis and demonstrated for the first time that L1 mobilization occurs in murine tumors.
In Mdr2-deficient mice, which spontaneously developed HCC, the loss of IL-6 in monocytes/KCs resulted in inhibition of IL-6/signal transducer and activator of transcription 3 signaling, decreased serum IL-6 levels, and delayed tumorigenesis.