|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Those patients, as well as 93 controls, were typed for HLA-DRB1 and -DQB1 genes to assess their possible contribution to the development/protection of T1D with/without autoimmune thyroiditis.
|
29958949 |
2018 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the combinations such as 'DRB1*10+AA' (PL: p=1.8×10<sup>-6</sup>; HT: p=0.003) and 'DRB1*15+AA' (PL: p=0.006; GD: p=0.011) were decreased in patients showing a protective association.
|
29174716 |
2018 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
When dividing patients with Hashimoto's thyroiditis (HT) into those with PGA (PGA-HT) vs. those with HT as monoglandular disease, significant differences for the DRB1*03 (pc=0.001) and DQA1*03 (pc=0.001) alleles were observed.
|
26317691 |
2016 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The frequencies of DRB1*08:03-DQB1*06:01 and DRB1*09:01-DQB1*03:03 haplotypes were significantly higher in HT patients, whereas those of DRB1*13:02-DQB1*06:04 and DRB1*15:01-DQB1*06:02 haplotypes were significantly lower in these patients than in the controls.
|
23380142 |
2013 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After identifying HLA-DRB1∗03:01 (HLA-DR3) and H2E(b) as susceptibility alleles for Tg-induced experimental autoimmune thyroiditis in transgenic mouse strains, we searched for naturally processed T cell epitopes with MHC class II-binding motif anchors and tested the selected peptides for pathogenicity in these mice.
|
21683551 |
2011 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Conducting the first research of this kind in a Greek population, our study tries to provide an evaluation of the prevalence of HT relating to HLA-DRB1*0405, and we report a relative risk of 2.7 for HT in a Greek population.
|
19254248 |
2009 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to investigate HLA-DRB1 and HLADQB1 gene polymorphisms in Northern Greek pediatric population with Hashimoto's thyroiditis (HT), we analyzed the distribution of these alleles in 17 patients and in 181 healthy subjects using polymerase chain reaction.
|
18599937 |
2008 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
A strong association between HT and DR4 (DRB1(*)04-DQB1(*)03-DQA1(*)03) was detected (P=6.79 x 10(-7), OR=1.98 (95% CI=1.51-2.59)); however, only borderline association of DR3 was found (P=0.050).
|
18449200 |
2008 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
LHGDN |
A strong association between HT and DR4 (DRB1(*)04-DQB1(*)03-DQA1(*)03) was detected (P=6.79 x 10(-7), OR=1.98 (95% CI=1.51-2.59)); however, only borderline association of DR3 was found (P=0.050).
|
18449200 |
2008 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*03 was also increased among JAT patients but did not reach statistical significance.
|
16649979 |
2006 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have demonstrated that the DRB1*04 allele is associated with autoimmune thyroiditis, and that there are genotypic differences regarding the presentation forms with a strong association between DRB1*04 and DQB1*03 and the atrophic form only.
|
15305234 |
2004 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the allele distribution of the following loci: CTLA-4 exon 1 A49G dimorphism, which resulted in an amino acidic exchange (Thr/Ala) in the leader peptide, CTLA-4 3' microsatellite, HLA DRB1 and DQB1 in 126 patients with HT and in 301 control subjects from an Italian population (Lazio region).
|
11288988 |
2001 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our studies show that HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis and implicate Tg as an important autoantigen.
|
9064334 |
1996 |