Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 56994
Gene Symbol: CHPT1
CHPT1 		0.010 Biomarker disease BEFREE Brainstem glioma-bearing rats treated with hAT-MSC.rCE and CPT-11 survived 5d more than rats treated with CPT-11 only (p=0.0018). 21664124 2012
Entrez Id: 79947
Gene Symbol: DHDDS
DHDDS 		0.010 Biomarker disease BEFREE Brainstem glioma-bearing rats treated with hAT-MSC.rCE and CPT-11 survived 5d more than rats treated with CPT-11 only (p=0.0018). 21664124 2012
Entrez Id: 29126
Gene Symbol: CD274
CD274 		0.010 Biomarker disease BEFREE PD-L1 staining was detected in 59.7% of brainstem glioma specimens (37/62). 29137285 2017
Entrez Id: 5077
Gene Symbol: PAX3
PAX3 		0.030 AlteredExpression disease BEFREE Collectively, these data suggest that regional Pax3 expression not only marks a novel subset of BSG but also contributes to PDGF-B-induced brainstem gliomagenesis. 25330836 2014
Entrez Id: 8842
Gene Symbol: PROM1
PROM1 		0.010 Biomarker disease BEFREE Development of a novel imaging agent using peptide-coated gold nanoparticles toward brain glioma stem cell marker CD133. 27721007 2017
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2 		0.010 Biomarker disease BEFREE Elacridar, an ABCG2 and ABCB1 inhibitor, significantly increases the efficacy of dasatinib in brainstem glioma-bearing ABC WT mice (42 vs. 59 days). 26883271 2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.010 Biomarker disease BEFREE Elacridar, an ABCG2 and ABCB1 inhibitor, significantly increases the efficacy of dasatinib in brainstem glioma-bearing ABC WT mice (42 vs. 59 days). 26883271 2016
Entrez Id: 10058
Gene Symbol: ABCB6
ABCB6 		0.010 Biomarker disease BEFREE Elacridar, an ABCG2 and ABCB1 inhibitor, significantly increases the efficacy of dasatinib in brainstem glioma-bearing ABC WT mice (42 vs. 59 days). 26883271 2016
Entrez Id: 10215
Gene Symbol: OLIG2
OLIG2 		0.010 Biomarker disease BEFREE Here we report that Olig2 expression and DIPG differentiation are mutually exclusive events in vitro, and only DIPG cells that retained Olig2 in vitro formed robust Olig2-positive brainstem glioma with 100% penetrance in a xenograft model. 28339768 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.120 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 90
Gene Symbol: ACVR1
ACVR1 		0.100 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1 		0.100 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 3020
Gene Symbol: H3-3A
H3-3A 		0.100 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.100 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.100 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 3418
Gene Symbol: IDH2
IDH2 		0.100 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		0.100 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 3417
Gene Symbol: IDH1
IDH1 		0.100 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 8354
Gene Symbol: H3C11
H3C11 		0.100 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.120 AlteredExpression disease BEFREE Immunofluorescence of p53 was shown activated following BGSCs differentiation. 29937714 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A 		0.010 Biomarker disease BEFREE In addition, hypoxia inducible factor-1α (HIF-1α) might be a potential upstream regulator of PAX3 in differentiated BGSCs under hypoxia. 29937714 2018
Entrez Id: 10763
Gene Symbol: NES
NES 		0.010 Biomarker disease BEFREE In an effort to elucidate unique characteristics of BSG, we conducted expression analysis of mouse PDGF-B-driven BSG and CG initiated in Nestin progenitor cells and identified a short list of expression changes specific to the brainstem gliomagenesis process, including abnormal upregulation of paired box 3 (Pax3). 25330836 2014
Entrez Id: 406900
Gene Symbol: MIR106B
MIR106B 		0.010 Biomarker disease BEFREE In conclusion, our studies provide evidence that miR-20a and miR-106b may serve as putative causative involvement of malignant progression of pediatric BSG, thereby serving as likely novel targets for constraining the rapid fatal course of pediatric BSG. 22825541 2012
Entrez Id: 80381
Gene Symbol: CD276
CD276 		0.010 Biomarker disease BEFREE In the non-diffuse brainstem glioma group, none of the eight WHO grade I specimens showed B7-H3 immunoreactivity and nine of the 24 WHO grade II specimens (37.5 %) showed B7-H3 immunoreactivity. 23232807 2013
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.010 AlteredExpression disease BEFREE In this study, the expression of β-catenin and E- and N-cadherin was detected in 40 brainstem glioma samples using immunochemistry and was further analyzed in 18 samples using reverse transcription-polymerase chain reaction. 23240619 2013