Collectively, these data suggest that regional Pax3 expression not only marks a novel subset of BSG but also contributes to PDGF-B-induced brainstem gliomagenesis.
Our research revealed that miR-20a and miR-106b (known to be closely related) were the two most robust upregulated miRNAs in pediatric BSG compared to adult subtype.
In this study, the expression of β-catenin and E- and N-cadherin was detected in 40 brainstem glioma samples using immunochemistry and was further analyzed in 18 samples using reverse transcription-polymerase chain reaction.